Anirudh Patir

TL;DR: A novel early onset lethal encephalopathy due to mutations in the microglial-associated protein NRROS is described, leading to death between the ages of 27 and 36 months.

TL;DR: A model of self-limiting acute brain inflammation optimized to study mechanisms underlying inflammation resolution is proposed as a tractable reductionist system to complement more complex models for further understanding how inflammation resolution in the brain is regulated and as a platform for in vivo testing/screening of candidate resolution-modifying interventions.

TL;DR: The results give a mechanistic insight into the association of RNASE4 polymorphisms with ALS and show that E48D-RNASE4 would probably be deleterious and cause ALS in individuals harbouring this polymorphism.

TL;DR: A model of self-limiting acute brain inflammation optimised to study mechanisms underlying inflammation resolution is proposed as a tractable reductionist system to complement more complex models for further understanding how inflammation resolution in the brain is regulated and as a platform for in vivo testing/screening of candidate resolution-modifying interventions.

TL;DR: Single-cell dual RNA sequencing is used to comprehensively define, for the first time, the monocyte and parasite transcriptional responses that underpin human monocyte-Toxoplasma encounters at the single cell level and report extreme transcriptional variability between individual monocytes.