A
Anisha Solanki
Researcher at UCL Institute of Child Health
Publications - 15
Citations - 290
Anisha Solanki is an academic researcher from UCL Institute of Child Health. The author has contributed to research in topics: Thymocyte & Sonic hedgehog. The author has an hindex of 9, co-authored 13 publications receiving 184 citations. Previous affiliations of Anisha Solanki include University College London.
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Journal ArticleDOI
Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation
Eleftheria Papaioannou,Diana C. Yánez,Diana C. Yánez,Susan Ross,Ching-In Lau,Anisha Solanki,Mira Manilal Chawda,Alex Virasami,Ismael Ranz,Masahiro Ono,Masahiro Ono,Ryan F.L. O'Shaughnessy,Ryan F.L. O'Shaughnessy,Tessa Crompton +13 more
TL;DR: An important role is established for Shh upregulation in preventing AD, by increased Gli-driven, Treg cell–mediated immune suppression, paving the way for a potential new therapeutic strategy.
Journal ArticleDOI
The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity
Anna L. Furmanski,Alessandro Barbarulo,Anisha Solanki,Ching-In Lau,Hemant Sahni,José Ignacio Saldaña,Fulvio D'Acquisto,Tessa Crompton +7 more
TL;DR: These data are important for understanding the molecular mechanisms of immunomodulation, particularly in tissues where Hh proteins or other Gli-activating ligands such as TGFβ are upregulated, including during inflammation, tissue damage and repair, and in tumour microenvironments.
Journal ArticleDOI
Sonic Hedgehog regulates thymic epithelial cell differentiation
José Ignacio Saldaña,Anisha Solanki,Ching-In Lau,Hemant Sahni,Susan Ross,Anna L. Furmanski,Masahiro Ono,Georg A. Holländer,Tessa Crompton +8 more
TL;DR: Treatment of human thymus explants with recombinant Shh or neutralising anti-Shh antibody indicated that the Hedgehog pathway is also involved in regulation of differentiation from DP to mature SP T cells in the humanThymus.
Journal ArticleDOI
IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation
Diana C. Yánez,Diana C. Yánez,Hemant Sahni,Susan Ross,Anisha Solanki,Ching-In Lau,Eleftheria Papaioannou,Alessandro Barbarulo,Rebecca Powell,Ulrike C. Lange,Ulrike C. Lange,David J. Adams,Martino Barenco,Masahiro Ono,Masahiro Ono,Fulvio D'Acquisto,Anna L. Furmanski,Anna L. Furmanski,Tessa Crompton +18 more
TL;DR: The interferon‐inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs and it is shown that IFITM proteins regulate murine CD4+ Th cell differentiation.
Journal ArticleDOI
Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh
Anisha Solanki,Diana C. Yánez,Susan Ross,Ching-In Lau,Eleftheria Papaioannou,Jiawei Li,José Ignacio Saldaña,Tessa Crompton +7 more
TL;DR: It is shown that Gli3 activity in mouse thymic epithelial cells (TECs) promotes positive selection and differentiation from CD4- CD8+ to CD4+ CD8− single-positive (SP4) cells in the fetal thymus and thatgli3 represses Shh, which signals to reduce T-cell receptor-mediated transcription during repertoire selection in mouse fetal thylakine.