A
Ann S. Wright
Researcher at Pfizer
Publications - 12
Citations - 349
Ann S. Wright is an academic researcher from Pfizer. The author has contributed to research in topics: Catalysis & Allosteric modulator. The author has an hindex of 8, co-authored 12 publications receiving 325 citations.
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Journal ArticleDOI
Convenient preparations of t-butyl esters and ethers from t-butanol
TL;DR: In this paper, a one-pot preparation of t-butyl esters and ethers is described that proceeds from the carboxylic acid or alcohol and tbutanol using only anhydrous magnesium sulfate and catalytic sulfuric acid as additional reagents.
Journal ArticleDOI
Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin.
Philip A. Carpino,Bruce Allen Lefker,Steven M. Toler,Lydia C. Pan,John R. Hadcock,Ewell R. Cook,Joseph DiBrino,Anthony Michael Campeta,Shari L. DeNinno,K.L. Chidsey-Frink,Hada William Andrew,John Inthavongsay,F.Michael Mangano,Michelle A. Mullins,David F. Nickerson,Oicheng Ng,C.M. Pirie,John A. Ragan,Colin R. Rose,David A. Tess,Ann S. Wright,Li Yu,Michael P. Zawistoski,Paul DaSilva-Jardine,Theresa C. Wilson,David D. Thompson +25 more
TL;DR: In this article, pyrazolinone-piperidine dipeptide derivatives were synthesized and evaluated as growth hormone secretagogues (GHSs) for the treatment of musculoskeletal frailty in elderly adults.
Journal ArticleDOI
Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
Lei Zhang,Gayatri Balan,Gabriela Barreiro,Brian P. Boscoe,Lois K. Chenard,Julie Cianfrogna,Michelle Marie Claffey,Laigao Chen,Karen J. Coffman,Susan E. Drozda,Joshua R. Dunetz,Kari R. Fonseca,Paul Galatsis,Sarah Grimwood,John T. Lazzaro,Jessica Mancuso,Emily Miller,Matthew R. Reese,Bruce N. Rogers,Isao Sakurada,Marc B. Skaddan,Deborah L. Smith,Antonia F. Stepan,Patrick Trapa,Jamison B. Tuttle,Patrick Robert Verhoest,Daniel P. Walker,Ann S. Wright,Margaret M. Zaleska,Kenneth R. Zasadny,Christopher L. Shaffer +30 more
TL;DR: A novel series of pyrazolopyrazines is herein disclosed as mGluR5 negative allosteric modulators (NAMs) that demonstrated robust efficacy in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-rendered Parkinsonian nonhuman primate model of l-DOPA-induced dyskinesia.
Journal ArticleDOI
Discovery and biological characterization of capromorelin analogues with extended half-lives.
Philip A. Carpino,Bruce Allen Lefker,Steven M. Toler,Lydia C. Pan,John R. Hadcock,Murray Marianne C,Ewell R. Cook,Joseph DiBrino,Shari L. DeNinno,K.L. Chidsey-Frink,Hada William Andrew,John Inthavongsay,Lewis Sharon K,F.Michael Mangano,Michelle A. Mullins,David F. Nickerson,Oicheng Ng,C.M. Pirie,John A. Ragan,Colin R. Rose,David A. Tess,Ann S. Wright,Li Yu,Michael P. Zawistoski,John C. Pettersen,Paul DaSilva-Jardine,Theresa C. Wilson,David D. Thompson +27 more
TL;DR: New tert-butyl, picolyl and fluorinated analogues of capromorelin, a short-acting growth hormone secretagogue (GHS), were prepared as part of a program to identify long-acting GHSs that increase 24-h plasma IGF-1 levels.
Journal ArticleDOI
Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.
Kimberly O. Cameron,Bruce Allen Lefker,Hua Z. Ke,Mei Li,Michael P. Zawistoski,Christina M. Tjoa,Ann S. Wright,Shari L. DeNinno,Vishwas M. Paralkar,Thomas A. Owen,Li Yu,David D. Thompson +11 more
TL;DR: Lead optimization led to the identification of CP-533536, 7f, a potent and selective EP(2) agonist, which demonstrated the ability to heal fractures when administered locally as a single dose in rat models of fracture healing.