Anna B. Pulimood

TL;DR: The type and frequency of granulomas, presence or absence of ulcers lined by epithelioid histiocytes and microgranULomas, and the distribution of chronic inflammation have been identified as histological parameters that can be used to differentiate tuberculosis and Crohn’s disease in mucosal biopsy specimens obtained at colonoscopy.

TL;DR: In this paper, butyrate metabolism was investigated in experimental colitis in mice, and colitis was induced in Swiss outbred white mice by oral administration of 4% dextran sulphate sodium (DSS), and colocytes isolated from colitic and normal control mice were incubated with [ 14 C]butyrate or glucose.

TL;DR: In this paper, a review of the available evidence regarding the usefulness and limitations of all these different modalities available for the evaluation of these two disorders is presented, as well as the parameters useful in distinguishing them in each of the different diagnostic modalities is crucial to accurate decision making.

TL;DR: Butyrate enema was found to be cytoprotective in DSS colitis, an effect partly mediated by suppressing activation of HSP70 and NF-kappaB, and a significant protection against the decrease in cell viability, increase in mucosal permeability, and polymorphonuclear neutrophil infiltration seen in D SS colitis.

TL;DR: In this paper, the authors examined histological criteria that would enable the diagnosis in mucosal biopsies and found that granulomas in CD were distributed throughout the colon, they were more frequent in the rectosigmoid than in TB.