Anna Bertolaso

TL;DR: The data support a pro-survival role of BCR signaling in MCL and suggest that this pathway might be a candidate for therapy and also suggest that Syk activation patterns might be different in M CL compared to other lymphoma subtypes.

TL;DR: This study described for the first time that B cells from human blood express significant amounts of DR3 in response to B cell receptor polyclonal stimulation and revealed a novel function ofTL1A in modulating B-cell proliferation in vitro, suggesting that TL1A may contribute to homeostasis of effector B- cell functions in immune response and host defense.

TL;DR: This microfluidic chip-based electrophoresis device is reliable for testing cases with dominant PCR products but is less sensitive than GeneScan in detecting clonal peaks in a polyclonal background for IGH PCR, or with complex IGK rearrangement patterns.

TL;DR: MIDIA was pro-pose as the first step in mutational screening of GIST because it allowed the detection of 75% of mutated cases (94% of deletions/insertions) in less than 30 minutes after polymerase chain reaction amplification and at a lower cost compared with denaturing high-pressure liquid chromatography and sequencing, which might then be used only for MIDIA-negative cases.

TL;DR: Overall, these data document the expression of the TL1A/DR3 axis in early-stage CLL and identify a novel function forTL1A as a negative regulator of leukemic cell proliferation that may influence the CLL physiopathology and clinical outcome at an early- stage disease.