Showing papers by "Anna Spada published in 1975"
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TL;DR: The serum triiodothyronine concentration was evaluated before and after thyrotrophin releasing hormone in patients with hypothalamic‐pituitary disorders and in normal controls.
Abstract: SUMMARY
The serum triiodothyronine concentration was evaluated before and after thyrotrophin releasing hormone in fifty-six patients with hypothalamic-pituitary disorders (thirty-four had secondary hypothyroidism, twenty-two were euthyroid) and in twenty-four normal controls.
Basal serum T3 was low in fifteen hypothyroid subjects and normal in the remainders. After TRH, serum T3 did not increase normally in twenty-five hypothyroid and in ten euthyroid patients; even the patients with normal or supranormal plasma TSH increase had significantly lower T3 responses than normal controls (P<0.0001 for hypothyroid, P<0.01 for euthyroid subjects).
The finding of low T3 response to TRH in some euthyroid patients with hypothalamic-pituitary disorders can perhaps identify cases of preclinical secondary hypothyroidism, probably due to low biological activity of released TSH.
30 citations