Showing papers by "Annarosa Leri published in 2018"

PDF

Open Access

Journal Article•DOI•

Notch Signaling Modulates the Electrical Behavior of Cardiomyocytes

[...]

Giulia Borghetti¹, Carol A. Eisenberg², Sergio Signore¹, Andrea Sorrentino¹, Keerat Kaur², Alejandro Andrade-Vicenty², John G. Edwards², Mriganka Nerkar², Khaled Qanud², Dong Sun², Polina Goichberg¹, Annarosa Leri¹, Piero Anversa¹, Leonard M. Eisenberg², Jason T. Jacobson², Jason T. Jacobson³, Thomas H. Hintze², Marcello Rota² - Show less +14 more•Institutions (3)

Brigham and Women's Hospital¹, New York Medical College², Westchester Medical Center³

01 Jan 2018-American Journal of Physiology-heart and Circulatory Physiology

TL;DR: The results indicate that the Notch transduction pathway interferes with outward K+ Kv currents, critical determinants of the electrical repolarization of myocytes, and represents an important regulator of the electrophysiological behavior of developing and adult myocytes.

...read moreread less

Abstract: We investigated the effects of Notch receptor signaling on the electrical properties of cardiomyocytes. Our results indicate that the Notch transduction pathway interferes with outward K+ Kv curren...

...read moreread less

15 citations