Hydrogels for biomedical applications.

This article reviews the recent trends, developments, and future applications of bio-based polymers produced from renewable resources. Bio-based polymers are attracting increased attention due to environmental concerns and the realization that global petroleum resources are finite. Bio-based polymers not only replace existing polymers in a number of applications but also provide new combinations of properties for new applications. A range of bio-based polymers are presented in this review, focusing on general methods of production, properties, and commercial applications. The review examines the technological and future challenges discussed in bringing these materials to a wide range of applications, together with potential solutions, as well as discusses the major industry players who are bringing these materials to the market.

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Current progress on bio-based polymers and their future trends

The use of amorphous solid dispersions: A formulation strategy to overcome poor solubility and dissolution rate

How smart do biomaterials need to be? A translational science and clinical point of view ☆

Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review

Pore structure and surface area of mannitol powder, granules and tablets determined with mercury porosimetry and nitrogen adsorption.

Microcrystalline cellulose and its microstructure in pharmaceutical processing

To study how water plasticization affects the molecular mobility and crystallization tendency of freeze-dried trehalose, sucrose, melibiose and cellobiose. Freeze-dried disaccharides were subjected to different relative humidity atmospheres and their physical stabilities were evaluated. Lyophilizate water sorption tendencies and glass transition temperatures were modeled using Brunauer-Emmett-Teller (BET) and Gordon-Taylor (GT) equations, respectively. Sucrose and cellobiose crystallization tendencies were compared by using the concept of reduced crystallization temperature (RCT), and the molecular mobilities of trehalose and melibiose were compared by measuring their T1H relaxation time constants. Based on the BET and GT models, water sorption tendency and the resulting plasticizing effect were different in sucrose when compared to the other disaccharides. Trehalose and melibiose exhibited generally slower crystallization rates when compared to sucrose and cellobiose. Amorphous melibiose was shown to be particularly stable within the studied water content range, which may have partly been caused by its relatively slow molecular mobility. Slow amorphous-to-crystalline transition rate is known to be important for lyoprotecting excipients when formulating a robust drug product. The physical stabilities of amorphous trehalose and melibiose even with relatively high water contents might make their use advantageous in this respect compared to sucrose and cellobiose.

The Effect of Water Plasticization on the Molecular Mobility and Crystallization Tendency of Amorphous Disaccharides

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jps.24243

Anne Juppo

Papers

Pore structure and surface area of mannitol powder, granules and tablets determined with mercury porosimetry and nitrogen adsorption.

Microcrystalline cellulose and its microstructure in pharmaceutical processing

The Effect of Water Plasticization on the Molecular Mobility and Crystallization Tendency of Amorphous Disaccharides

Formulation and Stability of Cytokine Therapeutics

A Solid-State NMR Study of Phase Structure, Molecular Interactions, and Mobility in Blends of Citric Acid and Paracetamol