Anne Marie S. Harding

TL;DR: In this paper, the authors found that ASIC2 and ASIC1a are associated in brain, and through its interaction with PSD-95, ASIC2 increased ASIC 1a localization in dendritic spines.

TL;DR: It is concluded that ASIC2a and -3 are the major ASIC subunits in cardiac dorsal root ganglia neurons and provide potential molecular targets to attenuate chest pain and deleterious reflexes associated with cardiac disease.

TL;DR: In this article, the effect of substitution of extracellular Cl− with the inert anion methanesulfonate (MeSO3−) was investigated and the results of substitution on native ASIC channels in hippocampal neurons mirrored those in heterologously expressed ASIC1a and altered acid-induced neuronal death.

TL;DR: It is found that cell surface ASIC3 is enriched in the lipid raft fraction, which suggests that PSD-95 and ASIC3 interact within lipid rafts and that this raft interaction is required for PSd-95 to modulate ASIC3.

TL;DR: It is found that ASIC2 increased cell surface levels of the channel when it is coexpressed with ASIC1a, and genetic deletion of ASIC2 reduced acid-evoked current amplitude in mouse hippocampal neurons, lending support to an emerging role of ASIC 2 in the targeting of ASICs to surface membranes.