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Annemarie Hekman
Researcher at Netherlands Cancer Institute
Publications - 24
Citations - 876
Annemarie Hekman is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 16, co-authored 24 publications receiving 873 citations.
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Journal ArticleDOI
Initial experience with treatment of human B cell lymphoma with anti-CD19 monoclonal antibody.
Annemarie Hekman,A. Honselaar,W. M. J. Vuist,J. J. Sein,Sjoerd Rodenhuis,W.W. ten Bokkel Huinink,R. Somers,Ph. Rümke,Cornelis J. M. Melief +8 more
TL;DR: Six patients with progressive B cell non-Hodgkin's lymphoma have been treated with an IgG2a mouse monoclonal antibody (mAb) against the B cell differentiation antigen CD19, with total doses varying from 225 mg to 1000 mg.
Journal ArticleDOI
Association of lactoferrin with other proteins, as demonstrated by changes in electrophoretic mobility.
TL;DR: Lact oferrin in a number of human body fluids was found to possess different electrophoretic mobilities, while being immunologically identical, due to the property of human lactoferrin to interact strongly with acidic macromolecules, forming complexes with a faster migration than the single protein.
Journal ArticleDOI
The Antigens of Human Seminal Plasma: With Special Reference to Lactoferrin as a Spermatozoa-Coating Antigen
Annemarie Hekman,Philip Rümke +1 more
Journal Article
Eradication of Large Human B Cell Tumors in Nude Mice with Unconjugated CD20 Monoclonal Antibodies and Interleukin 2
Erik Hooijberg,J. J. Sein,P. C. M. Van Den Berk,Augustinus A. M. Hart,M. A. Van Der Valk,W. M. Kast,C. J. M. Melief,Annemarie Hekman +7 more
TL;DR: This is the first report to show that unconjugated CD20 mAbs are to be preferred over uncon jugated CD19 mAbs, and interleukin 2 over GM-CSF in the combinational treatment of large B cell tumors.
Journal Article
Potentiation by interleukin 2 of Burkitt's lymphoma therapy with anti-pan B (anti-CD19) monoclonal antibodies in a mouse xenotransplantation model.
TL;DR: Results indicate that it is possible to enhance mAb-dependent effector systems in vivo with the lymphokine rIL-2, and suggest that the immunotherapeutic potential of monoclonal antibodies directed against the human pan-B-cell antigen CD19 is possible.