Antonio Galioto

TL;DR: A growing body of studies suggest that intracellular Mg may play a key role in modulating insulin-mediated glucose uptake and vascular tone, and it is suggested that a reduced intrace cellular Mg concentration might be the missing link helping to explain the epidemiological association between NIDDM and hypertension.

TL;DR: It is suggested that oral Mg improves endothelial function in diabetic elderly subjects and results in a significant improvement of the post-ischemic endothelial-dependent flow-mediated dilation.

TL;DR: Greater longevity and economic progress are accompanied by an increasing burden of CVD and other chronic diseases with an important decrease in quality of life, which should question the benefit of these additional years without quality.

TL;DR: The importance of the genetic contribution is demonstrated by the inheritance of low-risk cardiovascular profiles in centenarian offspring and lower prevalence of cardiovascular diseases in this population as compared with their spouses or with age-matched subjects without 100enarian parents.

TL;DR: Aging is accompanied by elevated homocysteine and oxidative stress levels similar to those observed in younger subjects with hypertension or diabetes mellitus, independent of age, and these conditions appear to accelerate the age-dependent increase in homocy steine and antioxidant stress.