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Antti Airola
Researcher at University of Turku
Publications - 103
Citations - 2902
Antti Airola is an academic researcher from University of Turku. The author has contributed to research in topics: Support vector machine & Kernel method. The author has an hindex of 24, co-authored 94 publications receiving 2413 citations. Previous affiliations of Antti Airola include Turku Centre for Computer Science & University of Oldenburg.
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Journal ArticleDOI
Toward more realistic drug–target interaction predictions
Tapio Pahikkala,Antti Airola,Sami Pietilä,Sushil Kumar Shakyawar,Agnieszka Szwajda,Jing Tang,Tero Aittokallio +6 more
TL;DR: In this paper, the effects of four factors that may lead to dramatic differences in the prediction results are investigated: (i) problem formulation (standard binary classification or more realistic regression formulation), (ii) evaluation data set (drug and target families in the application use case), (iii) evaluation procedure (simple or nested cross-validation) and (iv) experimental setting (whether training and test sets share common drugs and targets, only drugs or targets or neither).
Journal ArticleDOI
All-paths graph kernel for protein-protein interaction extraction with evaluation of cross-corpus learning
TL;DR: A detailed evaluation of the effects of training and testing on different resources is performed, providing insight into the challenges involved in applying a system beyond the data it was trained on, and several pitfalls that can make evaluations of PPI-extraction systems incomparable, or even invalid are identified.
Journal ArticleDOI
Comparative analysis of five protein-protein interaction corpora
TL;DR: This first comparative evaluation of the diverse PPI corpora is presented, performing quantitative evaluation using two separate information extraction methods as well as detailed statistical and qualitative analyses of their properties.
Proceedings ArticleDOI
Extracting Complex Biological Events with Rich Graph-Based Feature Sets
TL;DR: A system for extracting complex events among genes and proteins from biomedical literature, developed in context of the BioNLP'09 Shared Task on Event Extraction, which defines a wide array of features and makes extensive use of dependency parse graphs.
Journal ArticleDOI
Regularized Machine Learning in the Genetic Prediction of Complex Traits
Sebastian Okser,Tapio Pahikkala,Antti Airola,Tapio Salakoski,Samuli Ripatti,Tero Aittokallio +5 more
TL;DR: It is argued here that many medical applications of machine learning models in genetic disease risk prediction rely essentially on two factors: effective model regularization and rigorous model validation.