Anvita Kale

TL;DR: Data indicate that certain biochemical characteristics may be common to a spectrum of psychiatric disorders, and suggest supplementation of antioxidants and essential fatty acids might affect clinical outcome.

TL;DR: The parallel changes inBDNF levels in plasma and CSF indicate that plasma BDNF levels reflect the brain changes in BDNFLevels in schizophrenia, and significant negative correlation with the scores of baseline PANSS positive symptom subscales is observed.

TL;DR: The results suggest for the first time that DHA plays an important role in one carbon metabolism thereby influencing global DNA methylation in the placenta.

TL;DR: A broader mechanism (disturbed folic acid-vitamin B12-DHA balance) of altered one-carbon metabolism and one of its key consequential components, an increased homocysteine level that together with cortisol, can contribute to the neuropathology of psychosis is provided.

TL;DR: Excess maternal folic acid supplementation on a B(12) deficient diet increases oxidative stress in both mother and pups and increased maternal oxidative stress resulted in lower fetal brain DHA levels, which has implications for implications for neurodevelopmental disorders since micronutrients and DHA are important modulators for neural functioning.