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Archana A. Narkar
Researcher at Tata Memorial Hospital
Publications - 3
Citations - 156
Archana A. Narkar is an academic researcher from Tata Memorial Hospital. The author has contributed to research in topics: Apoptosis & Betulinic acid. The author has an hindex of 3, co-authored 3 publications receiving 144 citations.
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BRAF V600E Mutation in Papillary Thyroid Carcinoma: Significant Association with Node Metastases and Extra Thyroidal Invasion
Avik Chakraborty,Archana A. Narkar,Rita Mukhopadhyaya,Shubhada Kane,Anil K. D'Cruz,M. G. R. Rajan +5 more
TL;DR: The findings suggest that BRAFV600E is a prevalent genetic alteration in adult sporadic PTCs in Indian cohort and it may be responsible for the progression of classic variant of PTC to metastatic and poorly differentiated subtype and likely to have significant impact on its diagnostic and prognostic management.
Journal ArticleDOI
Betulinic acid induces apoptosis in human chronic myelogenous leukemia (CML) cell line K-562 without altering the levels of Bcr-Abl.
TL;DR: The rapid loss of MMP of K-562 cells upon treatment with BA shows the direct activation of apoptosis at the level of mitochondria, overcoming the resistance of the high levels of expression of Bcr-Abl.
Journal ArticleDOI
Protection of Ewing’s sarcoma family tumor (ESFT) cell line SK-N-MC from betulinic acid induced apoptosis by α-dl-tocopherol
TL;DR: It is suggested that BA initiates events at membrane level leading to induction of apoptosis, and the observed ineffectiveness of hydrophilic antioxidants and substantial protection by lipophilic antioxidants indicate involvement of membrane-associated damages that form the basis of BA-induced cytotoxicity.