A
Aristidis Moustakas
Researcher at Science for Life Laboratory
Publications - 158
Citations - 18211
Aristidis Moustakas is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: SMAD & Transforming growth factor. The author has an hindex of 61, co-authored 150 publications receiving 16346 citations. Previous affiliations of Aristidis Moustakas include Ludwig Institute for Cancer Research & Harvard University.
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Non-Smad TGF-β signals
TL;DR: Non-Smad signal transducers under the control of TGF-β provide quantitative regulation of the signalling pathway, and serve as nodes for crosstalk with other major signalling pathways, such as tyrosine kinase, G-protein-coupled or cytokine receptors.
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Smad regulation in TGF-beta signal transduction.
TL;DR: The inhibitory Smads (I-Smads) block phosphorylation of R-Smad by the receptors and promote ubiquitination and degradation of receptor complexes, thus inhibiting signalling.
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Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression
TL;DR: Some of the current mechanisms that mediate the process of EMT are presented and their relevance to cancer progression is discussed.
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The regulation of TGFβ signal transduction
TL;DR: In this paper, the authors review the mechanisms of TGFbeta signal transduction in metazoans and emphasize events crucial for embryonic development, including negative feedback regulation via inhibitory Smads.
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Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.
TL;DR: The aim of this review is to summarize some of the recent findings on the mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.