Armando Córdova

TL;DR: In this paper, a direct asymmetric reductive Manich-type reaction that allows for the formation of three contiguous stereocenters with high chemo-, diastereo-, and enantioselectivity is presented.

TL;DR: In this paper, a highly enantioselective catalytic asymmetric synthesis of 2 H -1-benzothiopyrans was presented, which achieved high yields with 91-98% ee.

TL;DR: The ability of amino acids to form nucleophilic enamines with aldehydes and ketones has been used in the development of asymmetric α-oxidation reactions with electrophilic oxidizing agents.

TL;DR: In this paper, it was shown that mesylates or tosylates of delta-hydroxy-L-norvaline esters spontaneously afford L-proline esters upon exposure to aqueous buffer in near quantitative yield.

TL;DR: The existence of off-cycle catalyst cooperativity in amine/metal combined catalysis is disclosed in this paper , where the experimental and density functional theory study of the amine and metal co-catalyzed enantioselective Michael/carbocyclization cascade reaction between allenes and α,β-unsaturated aldehydes reveals that the dual catalysts can perform off-cycled cooperativity that gives access to stable bicyclo[3.2.0]heptane species that limits the carbocycle product formation.