Pharmaceutical, cosmetic and cosmeceutical foamable compositions for topical application, containing, as an active ingredient, urea and/or a derivative thereof, processes of manufacturing these compositions and uses of these compositions in the treatment of various dermatological conditions such as, for example, conditions associated with dry skin and/or scalp.

Topical compositions of urea

A pharmaceutical composition for transdermal administration of a hormone (e.g., testosterone), which includes a quaternary ammonium compound as a penetration enhancer, and methods utilizing same for treating medical conditions in which elevating a hormone serum level is beneficial are disclosed.

Pharmaceutical composition and method for transdermal drug delivery

The invention relates to the hydrogenation of aromatic compounds, in particular the preparation of alicyclic polycarboxylic acids or esters of these, via ring hydrogenation of the corresponding aromatic polycarboxylic acids or esters of these, and also to catalysts suitable for this purpose.

Catalyst and method for hydrogenating aromatic compounds

The invention relates to a process 1-olefins b telomerization of compounds having conjugated double bonds with a telogen in the presence of a noble metal telomerization catalyst, hydrogenation of the telomer and cleavage of the hydrogenated intermediate. Use of he 1-olefin as comonomer.

Method for producing 1-olefins using palladium carbene compounds

The invention relates to a method for producing 1-olefins from 1-alkoxyalkanes, particularly for producing 1-octene from 1-alkoxyoctane, by effecting a base catalyzed elimination of alcohols.

Method for producing 1-olefins by catalytically splitting 1-alkoxyalkanes

A bisphosphite of the formula I wherein R1, R2, R3 and R4 are each hydrogen, an aliphatic, alicyclic, aliphatic-alicyclic, aromatic, aromatic—aromatic, aliphatic-aromatic hydrocarbon or heterocyclic or aliphatic-heterocyclic group having from 1 to 50 carbon atoms, F, Cl, Br, I, —CF3, —OR7, —COR7, —CO2R7, —CO2M, —SR7, —SO2R7, —SOR7, —SO3R7, —SO3M, —CO2NR7R8, NR7R8, N═CR7R8, NH2, where R1 to R4 are identical or different and may be covalently linked to one another; R7 and R8 are each hydrogen, a substituted or unsubstituted, aliphatic or aromatic hydrocarbon radical having from 1 to 25 carbon atoms, and may be identical or different; M is an alkali metal, alkaline earth metal, ammonium or phosphonium ion; Q is a substituted or unsubstituted divalent aliphatic, alicyclic, aliphatic-alicyclic, aromatic, aliphatic-aromatic hydrocarbon, heterocyclic or aliphatic-heterocyclic radical having from 1 to 50 carbon atoms where HO-Q-OH is a diol; W and X are each a substituted or unsubstituted aliphatic, alicyclic, aliphatic-alicyclic, aromatic, aromatic—aromatic, aliphatic-aromatic hydrocarbon, heterocyclic or aliphatic-heterocyclic radical having from 1 to 50 carbon atoms which may be identical or different or covalently linked to one another, provided that when the phosphite oxygens linked to W and X are each linked to an aromatic ring, then they are linked to different aromatic rings, metal complexes thereof, and a method for the hydroformylation of olefins.

Novel bisphosphite compounds and their metal complexes

The invention relates to phosphites of formula (I) and phosphite metal complexes, the production thereof, and the use thereof in catalytic reactions, especially in methods for hydroformylation of olefins.

Novel phosphite compounds and novel phosphite metal complexes

Benzo- and naphtho-bisphosphites and their complexes with sub-Group 4-8 metals are claimed. Benzo- and naphtho-bisphosphites of formulae (I) - (IV) and their complexes with sub-Group 4-8 metals are claimed. R - R = H, 1-50C aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic, aromatic-aromatic or aliphatic-aromatic hydrocarbons, F, Cl, Br, I, CF3, OR , COR , CO2R , CO2M, SR , SO2R , SOR , SO3R , SO3M, SO2NR R , NR R , N:CR R or NH2 with R - R and R - R optionally covalently bonded to each other; R and R = H or 1-25C optionally substituted aliphatic or aromatic hydrocarbons; M = alkali(ne earth) metal, ammonium or phosphonium; Q = divalent 1-50C aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic or aliphatic-aromatic hydrocarbon; W and X = 1-50C aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic, aromatic-aromatic or aliphatic-aromatic hydrocarbons which are optionally covalently bonded to each other.

Bisphosphites and Metal Complexes thereof

The invention relates to phosphites of formula (I) or (II) and their metal complexes, to the production and use of said phosphites as ligands in catalytic reactions, particularly in methods for the hydroformylation of olefins.

Novel phosphite compounds and the metal complexes thereof

PROBLEM TO BE SOLVED: To improve the effectiveness of a bisphosphite which is a satisfactory complex ligand as a rhodium-hydroformylation catalyst. SOLUTION: This bisphosphite is expressed by general formula I (wherein, Q is a 1-50C bivalent aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic, aromatic-aromatic, or aliphatic-aromatic hydrocarbon group; W and X may be the same or different, or combine mutually by a covalent bond and are each a 1-50C aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic, aromatic-aromatic, or aliphatic- aromatic hydrocarbon group) and further, this bisphosphite or bisphosphite metal complex is employed to advantage for the hydroformylation from 2-25C olefins to corresponding aldehydes.

Armin Borner

Papers

Novel bisphosphite compounds and their metal complexes

Novel phosphite compounds and novel phosphite metal complexes

Bisphosphites and Metal Complexes thereof

Novel phosphite compounds and the metal complexes thereof

Bisphosphite, its metal complex, and its use