A
Arnold L. Smith
Researcher at Boston Children's Hospital
Publications - 34
Citations - 3022
Arnold L. Smith is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Haemophilus influenzae & Aminoglycoside. The author has an hindex of 20, co-authored 34 publications receiving 2881 citations. Previous affiliations of Arnold L. Smith include University of Missouri & Novartis.
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Journal ArticleDOI
Effect of Aerosolized Recombinant Human DNase on Exacerbations of Respiratory Symptoms and on Pulmonary Function in Patients with Cystic Fibrosis
Henry J. Fuchs,Drucy Borowitz,David H. Christiansen,Edward M. Morris,Martha L. Nash,Bonnie W. Ramsey,Beryl J. Rosenstein,Arnold L. Smith,Mary Ellen B. Wohl +8 more
TL;DR: In patients with cystic fibrosis, the administration of rhDNase reduced but did not eliminate exacerbations of respiratory symptoms, resulted in slight improvement in pulmonary function, and was well tolerated.
Journal ArticleDOI
Defining a pulmonary exacerbation in cystic fibrosis.
Margaret Rosenfeld,Julia Emerson,Judy Williams-Warren,Margaret Pepe,Arnold L. Smith,A. Bruce Montgomery,Bonnie W. Ramsey +6 more
TL;DR: It is hoped that the proposed PEx score might serve as a standardized outcome measure for future clinical trials in cystic fibrosis, allowing meaningful comparisons of study results.
Journal ArticleDOI
Efficacy and Safety of Short-term Administration of Aerosolized Recombinant Human Deoxyribonuclease in Patients with Cystic Fibrosis
Bonnie W. Ramsey,Susan J. Astley,Moira L. Aitken,Wylie Burke,Andrew A. Colin,Henry L. Dorkin,Jay D. Eisenberg,Ronald L. Gibson,Ivan R. Harwood,Daniel V. Schidlow,Robert W. Wilmott,M. E. Wohl,Laura J. Meyerson,Steven Shak,Henry J. Fuchs,Arnold L. Smith +15 more
TL;DR: Recombinant human DNase I (rhDNase) reduces the viscosity of CF sputum in vitro and is associated with a decreased perception of dyspnea and an improved perception of well-being and administration for 10 days of aerosolized rhDNase improves lung function and is well tolerated.
Journal ArticleDOI
Predictive value of oropharyngeal cultures for identifying lower airway bacteria in cystic fibrosis patients.
Bonnie W. Ramsey,Kim R. Wentz,Arnold L. Smith,Mark A. Richardson,Judy Williams-Warren,Donna L. Hedges,Ronald L. Gibson,Gregory J. Redding,Karen Lent,Kim Harris +9 more
TL;DR: The results suggest that oropharyngeal cultures yielding R aeruginosa or S. aureus are highly predictive, but such cultures lacking these organisms do not rule out the presence of these pathogens in the lower airways of CF patients.
Journal ArticleDOI
Bioactivity of Gentamicin in Purulent Sputum from Patients with Cystic Fibrosis or Bronchiectasis: Comparison with Activity in Serum
TL;DR: Purulent sputum, whether from children with cystic fibrosis or adults which bronchiectasis, is more inhibitory than serum; the greater degree of binding, rather than differences in the composition or quantity of cations, explains this difference.