Prognostic Significance of Heart Rate Variability in Post-myocardial Infarction Patients

Cardioprotective efficacy of remote ischemic preconditioning (RIPC) remains controversial. Experimental studies investigating RIPC have largely monitored cardiovascular changes during index ischemia and reperfusion with little work investigating changes during RIPC application. This work aims to identify cardiovascular changes associated with autonomic nervous system (ANS) activity during RIPC and prior to index ischemia. RIPC was induced in anesthetized male C57/Bl6 mice by four cycles of 5 min of hindlimb ischemia using inflated cuff (200 mmHg) followed by 5 min reperfusion. Electrocardiography (ECG) and microcirculatory blood flow in both hindlimbs were recorded throughout RIPC protocol. Heart rate variability (HRV) analysis was performed using ECG data. Hearts extracted at the end of RIPC protocol were used either for measurement of myocardial metabolites using high‐performance liquid chromatography or for Langendorff perfusion to monitor function and injury during 30 min index ischemia and 2 h reperfusion. Isolated‐perfused hearts from RIPC animals had significantly less infarct size after index ischemia and reperfusion (34 ± 5% vs. 59 ± 7%; mean ± SE P

https://physoc.onlinelibrary.wiley.com/doi/pdf/10.14814/phy2.13085

Remote ischemic preconditioning triggers changes in autonomic nervous system activity: implications for cardioprotection

https://research-information.bris.ac.uk/files/205811786/Full_text_PDF_final_published_version_.pdf

Neuro-autonomic changes induced by remote ischemic preconditioning (RIPC) in healthy young adults: Implications for stress.

Gender peculiarities of spectral indexes of heart rate variability (for girls higher T, HF and %HF, for boys %VLF and %ULF), stroke volume (for girls higher %HF), amplitude of aorta pulsation (for girls higher T, ULF, VLF, LF and HF) and micro vessel pulsation amplitude (for boys higher T, ULF, VLF, LF, HF and %LF, and for girls %ULF) have been revealed during examination of healthy young people in rest.

Медленные колебания гемодинамики у юношей и девушек в условиях покоя

/pdf/physiological-characteristics-of-regulation-of-emotional-xyajmobena.pdf

Physiological characteristics of regulation of emotional responses among specialists of extreme profile

Researched physiological mechanisms of development of orthostatic tachycardia syndrome (POTS) on the basis of a complex spectral structure analysis of heart rate variability (HRV), its nonlinear behavior in relationship to energy oscillations, baroreflex and parasympathetic activity. There were several stages of research. The first stage: created the method of spectral analysis of individual components of Very Low Frequency (VLF). On the basis of comparative Fast Furrier Transform data with Welch filters, autoregression, continuous wavelet analysis and Hilbert–Huang transform, for the first time it was shown that VLF has separate 200, 100 and 50 s oscillations (VLF200, VLF100, VLF50). The second stage: for evaluation of physiological properties of separate oscillations, was analyzed VLF structure in three groups of patients (100 subjects): with a predominance of parasympathetic activity (HF) in the HRV spectrum; with a dominance of 10 s oscillations (LF); with a severe depression of  energy in all components of the spectrum. It was established that the individual components of VLF (VLF100 and VLF50) have a certain stability and partial independence from the changes of peripheral autonomic indices (LF/HF) at loads of low intensity. The third stage: at an active orthostatic test, 20 subjects with orthostatic tachycardia were researched in a comparison to a control group of 20 subjects without tachycardia. Analyzed the specifics of the VLF structure (VLF100 and VLF50) alone and in a conjunction with the LF and HF, as well as heart rate and blood pressure in subjects with orthostatic tachycardia with a predominance of parasympathetic activity at functional tests of low intensity (seven-test, deep breathing) and at an active orthostatic test. Based on these studies it was concluded that the individual components in the VLF structure (VLF100, VLF50) can demonstrate reciprocal relationships at a load among themselves and in the LF/HF ratio, and play an adaptive role in the mechanisms of autonomic provision. Revealed the importance of VLF and its components 100 and 50 s oscillations at an orthostatic test in the prognosis of orthostatic tachycardia development. In patients with dysautonomia at high level of VLF100 power, or high VLF50 indices, tachycardia did not develop. In this case, VLF and its component parts did an important adaptive function and conversely, the low VLF50 indices contribute to orthostatic tachycardia. In the proposed model of the descending neurosomatic control of autonomic regulation of HRV a very important role plays both neurogenic ways of regulation, and neuro-hormonal-metabolic ways, manifested in the complex VLF structure. Regarded the choice of ways and optimal neurosomatic models of regulation at POTS.

/pdf/ortostaticheskaia-takhikardiia-diagnosticheskoe-i-5653wr16m7.pdf

Ортостатическая тахикардия: диагностическое и прогностическое значение very low Frequency вариабельности ритма сердца

FIELD: medicine SUBSTANCE: invention relates to medicine, namely to cardiology, and can be used for assessing adaptive-compensatory reactions in healthy individuals on remote pre-conditioning One performs test with arterial occlusion by applying cuff on upper part of hand Occlusion is created by lifting pressure up to 200 mm Hg during 5 minutes, followed by reperfusion during 5 minutes Cycle is carried out three times Microcirculation parameters are measured by laser Doppler flowmetry (LDF) and content of porphyrins at wavelengths 710, 640 and 680 nm is measured by laser fluorescence (LF) by means of multifunctional laser diagnostic complex "LAKK-M" Sensor is placed on palmar surface of left hand index finger in patient lying flat on back after 5-minute adaptation period in room at temperature +23…+24 °C By LDF parameters microcirculation is calculated: microcirculation value (MV), mean square deviation (MSD), value of microvascular tone (MT) and intravascular resistance (Rc) Values before and after pre-conditioning are compared If observing rise of after pre-conditioning indices MV, MSD, MT, reduction of Rc, reduction of content of porphyrins in all wavelengths, compensatory-adaptive reaction is assessed as normal in response to acute short-term hypoxia in healthy individuals EFFECT: method enables determining adaptation body potential and remote pre-conditioning in healthy individuals by assessing microcirculation and redox processes 1 cl, 7 dwg, 5 tbl, 3 ex

Арнольд Наумович Флейшман

Papers

Ортостатическая тахикардия: диагностическое и прогностическое значение very low Frequency вариабельности ритма сердца

Method of estimating adaptive-compensatory reactions in healthy individuals to remote pre-conditioning