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Arthur I. Cederbaum
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 375
Citations - 27906
Arthur I. Cederbaum is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Oxidative stress & Lipid peroxidation. The author has an hindex of 73, co-authored 375 publications receiving 26362 citations. Previous affiliations of Arthur I. Cederbaum include City University of New York & Rutgers University.
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Journal ArticleDOI
Increased oxidation of dimethylnitrosamine in pericentral microsomes after pyrazole induction of cytochrome P-4502E1.
Elisa Dicker,Arthur I. Cederbaum +1 more
TL;DR: Experiments were conducted to evaluate whether microsomes isolated from the pericentral region of the liver display elevated catalytic activity towards effective substrates for CYP2E1 such as dimethylnitrosamine (DMN) as compared with periportal microsome.
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Increased oxidation of ethylene glycol to formaldehyde by microsomes after ethanol treatment: role of oxygen radicals and cytochrome P450.
Ewa Kukielka,Arthur I. Cederbaum +1 more
TL;DR: It is suggested that microsomes from ethanol-treated rats are more reactive than pair-fed controls in generating ferryl-type oxidants and that increased production of H2O2 by cytochrome P4502E1 plays a role in the elevated oxidation of ethylene glycol to formaldehyde.
Journal Article
Sensitivity of the rat liver microsomal oxidation of pyrazole to antibody raised against the ethanol-inducible rabbit liver cytochrome P-450 isozyme.
TL;DR: The induction pattern suggests that pyrazole may be an effective substrate for oxidation by P-450 IIE, which is recognized by antibody (anti-3a IgG) raised against the ethanol-inducible P- 450 in rabbits.
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Redox-Cycling of Iron Ions Triggers Calcium Release From Liver Microsomes
TL;DR: Results suggest that redox-cycling of iron ions results in an activation of a ryanodine-sensitive calcium channel, which may play a role in the evolution of various hepatic disorders that are associated with chronic iron overload in humans.
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Temperature dependence of the microsomal oxidation of ethanol by cytochrome P450 and hydroxyl radical-dependent reactions.
TL;DR: The results suggest that the increase in microsomal ethanol oxidation by pyrazole treatment is not associated with any apparent change in the overall mechanism or rate-limiting step for ethanol oxidation but likely reflects induction of a P450 isozyme with increased activity toward ethanol.