A
Asghar Ghorbani
Researcher at Tehran University of Medical Sciences
Publications - 5
Citations - 185
Asghar Ghorbani is an academic researcher from Tehran University of Medical Sciences. The author has contributed to research in topics: Hesperidin & Gene. The author has an hindex of 3, co-authored 4 publications receiving 156 citations. Previous affiliations of Asghar Ghorbani include Shahid Beheshti University of Medical Sciences and Health Services.
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The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ-dependent mechanism.
TL;DR: The findings of this study clearly demonstrate that hesperidin-mediated proapoptotic and antiproliferative actions are regulated via both PPARγ-dependent and PParγ-independent pathways in NALM-6 cells.
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Inactivation of nuclear factor-κB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells.
TL;DR: It is found that incubation of Ramos cells with hesperidin abrogates constitutive and doxorubicin-induced NF-κB activation through inhibition of phosphorylation of its inhibitory subunits (IκB) and resulted in inhibition of proliferation and apoptosis in a PPARγ-independent way.
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Relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin
TL;DR: The results indicated p53 activation in the peripheral tissues of obese subjects as a protective mechanism against chronic insulin elevation, suggested that p53 could be a new target for the treatment of type 2 diabetes.
Prediction of Psychological Well-Being Based on Islamic Lifestyle and Coping Strategies in Patients with Major Thalassemia in Tehran
TL;DR: The study predicted and found that the Islamic lifestyle has a positive psychological well-being in patients with thalassemia major and among coping strategies, coping focused on problem-solving, cope focused on positive cognitive assessment, and coping with physical inhibition.
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Mutational Spectrum and Clinical Symptoms of Iranian Patients with Charcot-Marie-Tooth Disease: A Study of 23 Patients
TL;DR: In this article , a comprehensive gene panel sequencing consisting of 80 genes in a cohort of 23 patients with Charcot-Marie-Tooth (CMT) referred between January 2015 and March 2021 was conducted to identify the clinical manifestation, mutational spectrum and phenotypic correlation of patients with CMT.