In the article “Early development of intractable epilepsy in children: A prospective study” by Berg et al. ( Neurology 2001;56:1445–1452), several errors appeared in the …

Early development of intractable epilepsy in children: A prospective study

In the article “Levetiracetam in pregnancy: Results from the UK and Ireland epilepsy and pregnancy registers” by E. Mawhinney et al. ( Neurology® 2013;80:400–405), there is an error in the body of the abstract and in table 1. The polytherapy major congenital malformations (MCM) rate should read 5.56% (3.54%–8.56%) rather than 6.47% (4.31%–9.60%). The authors regret the errors.

https://n.neurology.org/content/neurology/80/7/691.full.pdf

Levetiracetam in pregnancy: Results from the UK and Ireland epilepsy and pregnancy registers

Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. The bidirectional mechanisms that are likely to underlie this extensive comorbidity between migraine and other diseases are manifold. Comorbid pathologies can induce and promote thalamocortical network dysexcitability, multi-organ transient or persistent pro-inflammatory state, and disproportionate energetic needs in a variable combination, which in turn may be causative mechanisms of the activation of an ample defensive system with includes the trigeminovascular system in conjunction with the neuroendocrine hypothalamic system. This strategy is designed to maintain brain homeostasis by regulating homeostatic needs, such as normal subcortico-cortical excitability, energy balance, osmoregulation, and emotional response. In this light, the treatment of migraine should always involves a multidisciplinary approach, aimed at identifying and, if necessary, eliminating possible risk and comorbidity factors.

/pdf/pathophysiological-bases-of-comorbidity-in-migraine-3abd9vw6p2.pdf

Pathophysiological Bases of Comorbidity in Migraine.

Bidirectional relationships of sleep and epilepsy in adults with epilepsy.

Background
Yawning is considered to be a symptom that reflects dopaminergic activity, although its pathophysiological mechanism is not yet fully understood Interestingly, repetitive yawning is seen in some patients during migraine attacks The aim of this cross-sectional study is to investigate the frequency of yawning during migraine attacks and its association with different characteristics of migraine

Methods
Patients with migraine with or without aura were evaluated using questionnaires and diaries to determine the characteristics of headache and accompanying symptoms Repetitive yawning in the premonitory phase and/or during headache were determined

Results
Three hundred and thirty-nine patients were included in the study One hundred and fifty-four patients reported repetitive yawning (454%) during migraine attacks Repetitive yawning was reported in the 112% of the patients in the premonitory phase, 242% during headaches, and 10% both in the premonitory phase and during headaches Migraine with aura (468 vs 319%; P = 005), accompanying nausea (896 vs 751%; P = 001), vomiting (487 vs 378%; P = 044), osmophobia (667 vs 523%; P = 024), and cutaneous allodynia (582 vs 46%; P = 032) were more common in patients with yawning than without Other dopaminergic-hypothalamic premonitory symptoms (416 vs 265%; P = 003), especially sleepiness (175 vs 59%; P = 001), irritability/anxiety (214% vs 114%; P = 019), nausea/vomiting (104 vs 43%; P = 03), and changes in appetite (182 vs 97%; P = 024), were also more frequent in patients with yawning than without After being adjusted for all other relevant covariates, the odds of repetitive yawning were increased by the presence of nausea (OR 288; 95% CI 1453-5726; P = 002) and migraine with aura (OR 166; 95% CI 1035-2671; P = 036)

Conclusions
Our results demonstrated that yawning is a common self-reported symptom leading or accompanying migraine attacks and is associated with aura, nausea and/or vomiting, osmophobia, and cutaneous allodynia in patients with migraine Although yawning is a rather frequently seen behavior, it is a unique and reliable symptom in patients with migraine that may offer an opportunity for early treatment of migraine attacks

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Papers

Headache in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.