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Atsushi Sasaki
Researcher at Eisai
Publications - 38
Citations - 617
Atsushi Sasaki is an academic researcher from Eisai. The author has contributed to research in topics: Liposome & Alkyl. The author has an hindex of 12, co-authored 38 publications receiving 605 citations.
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Patent
Selective estrogen receptor modulators
TL;DR: In this article, the general formula (I), salts thereof, and hydrates of both: (I) wherein T is a single bond, optionally substituted C1-4 alkylene, or the like; the symbols ˙˙ ǫ˫˒˔˒ ˫ are each a single or a double bond; A is a divalent group derived from a 5- to 14-membered heterocycle which may be substituted, or a like; Y is a one-to-four independent hydrogen atoms or the
Journal ArticleDOI
Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives.
Hachiro Sugimoto,Yutaka Tsuchiya,Hiroyuki Sugumi,Kunizo Higurashi,Norio Karibe,Youichi Iimura,Atsushi Sasaki,Y Kawakami,T Nakamura,Shin Araki +9 more
TL;DR: Compound 21 showed an affinity 18,000 times greater for AChE than for BuChE and produced a marked and significant increase in acetylcholine (ACh) content in the cerebral vortex and hippocampus of rats, chosen for advanced development as an antidementia agent.
Journal ArticleDOI
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine, and related derivatives
Hachiro Sugimoto,Yutaka Tsuchiya,Hiroyuki Sugumi,Kunizo Higurashi,Norio Karibe,Yoichi Iimura,Atsushi Sasaki,Shin Araki,Yoshiharu Yamanishi,Kiyomi Yamatsu +9 more
TL;DR: One of the compounds prepared in this series, 1-benzyl-4-[2-[4-(benzoylamino)phthalimido]ethyl]piperidine hydrochloride (19) (IC50 = 1.2 nM) is one of the most potent inhibitors of AChE.
Patent
Selective estrogen receptor modulator
Shinichi Hamaoka,Noritaka Kitazawa,Kazumasa Nara,Atsushi Sasaki,Atsushi Kamada,Tadashi Okabe +5 more
TL;DR: In this paper, a compound represented by the following formula (I) is described: T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like.
Journal ArticleDOI
Pharmacokinetics of novel hexapeptides with neurotensin activity in rats.
TL;DR: It was found that NT-1 was more suitable for oral administration than NT-2, and the pharmacokinetic profiles of NT- 2 after intravenous administration ofNT-1 at doses of 0.1 and 0.3 mg/kg were compatible with that of NT (Me)Arg-Lys-Pro-Trp-tert-leu-Leu- Leu-OEt.