Avi Nahum

TL;DR: In this model of lung injury induced solely by mechanical forces, the prone position resulted in a less severe and more homogeneous distribution of ventilator‐induced lung injury, which parallel those previously obtained in oleic acid‐preinjured animals ventilated with higher positive end‐expiratory pressure.

TL;DR: Responses to PEEP, VT, and RM differ among these models of acute lung injury, suggesting that RM may have a role in some patients with ARDS who are ventilated with low PEEP and low VT.

TL;DR: It is concluded that the ventilatory strategy most likely to overdistend the lungs while allowing repetitive opening and closure of alveoli (group 2) facilitated bacterial translocation from theAlveoli to the bloodstream and increased lung injury, as determined by histologic and gravimetric analysis.

TL;DR: Tracheal gas insufflation may eventually prove a useful adjunct to a pressure-targeted strategy of ventilatory management (in either volume-cycled or pressure controlled modes), particularly when the total dead space is heavily influenced by its anatomic component.

TL;DR: The results suggest that a RM improves oxygenation more effectively with a decreased PEEP requirement for the preservation of the oxygenation response in prone compared with supine position.