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Avmeet Kohli
Researcher at Jawaharlal Nehru University
Publications - 4
Citations - 420
Avmeet Kohli is an academic researcher from Jawaharlal Nehru University. The author has contributed to research in topics: Candida albicans & Membrane fluidity. The author has an hindex of 4, co-authored 4 publications receiving 395 citations.
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Drug susceptibilities of yeast cells are affected by membrane lipid composition
TL;DR: It appears that multidrug resistance in yeast is closely linked to the status of membrane lipids, wherein the overall drug susceptibility phenotype of a cell appears to be an interplay among drug diffusion, extrusion pumps, and the membrane lipid environment.
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In Vitro Low-Level Resistance to Azoles in Candida albicans Is Associated with Changes in Membrane Lipid Fluidity and Asymmetry
TL;DR: The results of the present study suggest for the first time that changes in the status of membrane lipid phase and asymmetry could contribute to azole resistance in C. albicans.
Journal ArticleDOI
Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation.
Vinita Gupta,Avmeet Kohli,Shankarling Krishnamurthy,Neeti Puri,Syed Ahmed Aalamgeer,Snehlata Panwar,Rajendra Prasad +6 more
TL;DR: The complete sequencing of CaMDR1 alleles revealed several in-frame point mutations leading to a change in amino-acid residues where insertion/replacement of an aspartate residue in a serine-asparagine-aspartate-rich domain was most noteworthy.
Journal ArticleDOI
Specificity of drug transport mediated by CaMDR1: a major facilitator of Candida albicans.
Avmeet Kohli,Vinita Gupta,Shankarling Krishnamurthy,Seyed E. Hasnain,Seyed E. Hasnain,Rajendra Prasad +5 more
TL;DR: It is demonstrated for the first time that CaMDR1p can mediate methotrexate (MTX) and fluconazole (FLC) transport and that MTX is preferentially transported by CaMdr1p, it can be used for studying the function of this MFS protein.