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B.A. de Jong
Researcher at Radboud University Nijmegen
Publications - 3
Citations - 2240
B.A. de Jong is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Epitope & Antigen. The author has an hindex of 3, co-authored 3 publications receiving 2159 citations.
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Journal ArticleDOI
Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies.
G.A. Schellekens,B.A. de Jong,F.H.J. van den Hoogen,L. B. A. Van De Putte,W. J. Van Venrooij +4 more
TL;DR: It is shown that autoantibodies reactive with synthetic peptides containing the unusual amino acid citrulline, a posttranslationally modified arginine residue, are specifically present in the sera of RA patients, and the presence of these antibodies early in disease, even before other disease manifestations occur, are indicative for a possible role of citrulling epitopes in the pathogenesis of RA.
Journal ArticleDOI
Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study.
F. A. van Gaalen,S.P. Linn-Rasker,W. J. Van Venrooij,B.A. de Jong,Ferdinand C. Breedveld,Cornelis L. Verweij,René E. M. Toes,Tom W J Huizinga +7 more
TL;DR: Testing for anti-CCP antibodies in UA allows accurate prediction of a substantial number of patients who will fulfill the ACR criteria for RA.
Journal Article
Mapping of B cell epitopes on small nuclear ribonucleoproteins that react with human autoantibodies as well as with experimentally-induced mouse monoclonal antibodies.
TL;DR: Ind immunized a genetically non-autoimmune mouse with recombinant human B" protein and obtained three mAb reactive with native U2 snRNP particles, implying that the mAb define a major autoantibody-reactive region on protein B".