So far in this course we have dealt entirely with the evolution of characters that are controlled by simple Mendelian inheritance at a single locus. There are notes on the course website about gametic disequilibrium and how allele frequencies change at two loci simultaneously, but we didn’t discuss them. In every example we’ve considered we’ve imagined that we could understand something about evolution by examining the evolution of a single gene. That’s the domain of classical population genetics. For the next few weeks we’re going to be exploring a field that’s actually older than classical population genetics, although the approach we’ll be taking to it involves the use of population genetic machinery. If you know a little about the history of evolutionary biology, you may know that after the rediscovery of Mendel’s work in 1900 there was a heated debate between the “biometricians” (e.g., Galton and Pearson) and the “Mendelians” (e.g., de Vries, Correns, Bateson, and Morgan). Biometricians asserted that the really important variation in evolution didn’t follow Mendelian rules. Height, weight, skin color, and similar traits seemed to

Human biochemical genetics

Advanced Statistical Methods in Biometric Research.

Background: A large proportion of global increase in thyroid cancer (TC) incidence has been attributed to increased detection of papillary thyroid cancer (PTC). Nonetheless, some reports support a real increase in incidence. This study aimed to perform a systematic review to evaluate the changing trends in TC incidence and summarize potential risk factors predisposing to this trend. Methods: Literature published in the English language between 1980 and August 2014 was searched via PubMed (MEDLINE) and OvidSP (EMBASE). Original studies on changes in TC incidence in defined geographic areas that described clear methods of case selection and population estimates were included. Data on incidence rates and risk factors were collected. Results: Of 4719 manuscripts, 60 studies were included, of which 31 were from Europe, 13 from North America, and the rest from Asia (n = 9), Oceania (n = 4), and South America (n = 3). Fifty-three articles reported a significant increase in incidence (highest was a 10-fold increa...

Systematic Review of Trends in the Incidence Rates of Thyroid Cancer

Anatomy and Physiology in Health and Illness

Thank you for downloading foetus into man physical growth from conception to maturity. As you may know, people have look numerous times for their chosen novels like this foetus into man physical growth from conception to maturity, but end up in infectious downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they are facing with some malicious virus inside their desktop computer.

https://adc.bmj.com/content/archdischild/54/9/731.1.full.pdf

Foetus into Man: Physical Growth from Conception to Maturity

Background: Dermatoglyphics is widely used as a genetically determined trait in Anthropology. However, little is known about their pattern of inheritance due to lack of advanced statistical genetic model-fitting techniques despite the existence of advanced statistical packages. Objectives: The aim of the present study is to determine the mode of inheritance of dermatoglyphic traits through complex segregation analysis. Subjects and Methods: Finger and palmar prints of 325 individuals belonging to 104 families from the Chuvashian popu- lation of Russia were used for principal component analysis, familial correlation, and segregation analysis (package MAN-5). Results: The results suggest a common internal structure of three factors when compared with other populations. (b) Sig- nificant familial correlations (except spouse) indicate the involvement of familial components to the variation of dermato- glyphic traits. (c) Segregation analysis reveals the transmission of genetic effects in the families, which follows the Men- delian model and confirm major gene effect on factors 1 and 2, whereas there is no evidence of major gene effect or an environmental effect on factor 3. Conclusion: Major gene involvement with Mendelian expectation regarding finger dermatoglyphics is confirmed for all analyzed traits. However there is no evidence of significant support for major gene effect or environmental effect on pal- mar a-b ridge counts.

Genetic Determinants of 22 Quantitative Dermatoglyphic Traits in the Chuvashian Population of Russia: Complex Segregation Analysis

The paper deals with the bilateral palmar prints of 3000 males belonging to 20 Dhangar castes of Maharashtra which were analysed (1) to compare the pattern of variation of palmar triradii with respect to other traits, (2) to examine the degree of similarity between clusters based on dermatoglyphics anthropometry and genetic markers and (3) relating these similarities with their ethnographic and geographic proximities. The results of this study confirm the general presumptions, (a) that dermal traits, in general, and palmar characters, in particular, do help in understanding the biologic/ethnic affinities among different groups both at macro and micro levels and (b) the different types of traits, which are likely to be influenced by different genetic and/or environmental factors give rise to different clustering patterns.

Distribution and population variation of total number of palmar triradii among 20 Dhangar castes of Maharashtra, India

The aim of this study is to compare the pattern of sex differences between two different sets of dermatoglyphic traits (22 quantitative and 42 indices of diversity and asymmetry). Finger and palmar prints of Turkmenian population (547 individuals) were used for Multivariate analyses includes Cluster, Discriminant and Mantel test of matrix correlations. All variables (two groups) scattered into a number of small clusters those are markedly similar between males and females. These results were confirmed by Discriminant analysis - the two groups of variables are almost similar, the percentages of correctly classified individuals are 64.14% (22 traits) and 65.45% (42 traits); and Mantel statistics - the Z values are within the level of non-significance, very good similarities in 22 (0.95) and good similarities in 42 (0.87) traits. Sex dimorphism is similar between two categories of dermatoglyphic variables may be used for sex - discrimination in different populations.

/pdf/sexual-dimorphism-in-the-turkmenian-population-in-two-types-5309pa33rc.pdf

Sexual dimorphism in the Turkmenian population in two types of dermatoglyphic traits: discriminant analysis.

Quantitative Fluctuating (FA) and Directional asymmetry (DA) of dermatoglyphics on digito-palmar complex were analyzed in a group of 111 patients (males: 61, females: 50) with schizophrenia (SZ), and compared to an ethnically matched phenotypically healthy control (males: 60, females: 60) through MANOVA, ANOVA and canonical Discriminant analyses. With few exceptions, asymmetries are higher among patients, and this is more prominent in FA than DA. Statistically significant differences were observed between patient and control groups, especially in males. In both sexes, FA of combined dermatoglyphic traits (e.g. total finger ridge count, total palmar pattern ridge count) are found to be a strong discriminator between the two groups with a correct classification of over 83% probability.

Quantitative dermatoglyphic asymmetry: a comparative study between schizophrenic patients and control groups of West Bengal, India.

Bilateral palmar prints of 2927 males of 20 endogamous Dhangar castes of Maharashtra, India, were studied for the distributions of a-b, b-c and c-d interdigital ridge-counts. The ridge-counts have been utilized for examining the inter-population affinities among the Dhangar castes. The distribution of a-b ridge-counts is symmetrical and normal in Dhangar castes. The distributions of b-c and c-d ridge-counts on both palms also show (nearly) normal distribution, but with a tendency of negative skewness and platykurtosis in c-d ridge-count. Equality of means and standard deviations depict significant heterogeneity. The decreasing order of magnitude of means of interdigital ridge-counts is a-b > c-d > b-c among all the Dhangar castes. Intercaste comparisons reveal a great deal of variations in all ridge-counts. The pattern of relationship between the Dhangar castes based on the three ridge-counts is in agreement with the expected patterns of affinities based on the known ethno-historical evidence. The significant finding of the study is that the palmar interdigital ridge-counts follow normal distribution and that they are useful in studying inter-population affinities.

B. Karmakar

Papers

Genetic Determinants of 22 Quantitative Dermatoglyphic Traits in the Chuvashian Population of Russia: Complex Segregation Analysis

Distribution and population variation of total number of palmar triradii among 20 Dhangar castes of Maharashtra, India

Sexual dimorphism in the Turkmenian population in two types of dermatoglyphic traits: discriminant analysis.

Quantitative dermatoglyphic asymmetry: a comparative study between schizophrenic patients and control groups of West Bengal, India.

Variation in palmar interdigital ridge-counts among the 20 Dhangar castes of Maharashtra, India.