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Babine Robert E
Researcher at General Atomics
Publications - 11
Citations - 1090
Babine Robert E is an academic researcher from General Atomics. The author has contributed to research in topics: Protein ligand & Crystal structure. The author has an hindex of 7, co-authored 11 publications receiving 1061 citations.
Papers
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Journal ArticleDOI
Molecular recognition of protein-ligand complexes : applications to drug design
Babine Robert E,Steven L. Bender +1 more
Journal ArticleDOI
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure−Activity Studies
Peter S. Dragovich,Stephen E. Webber,Babine Robert E,Shella A. Fuhrman,Amy K. Patick,David A. Matthews,Caroline A. Lee,Reich Siegfried Heinz,Thomas J. Prins,Joseph T. Marakovits,Littlefield Ethel S,Ru Zhou,Jayashree Tikhe,Clifford E. Ford,Wallace Michael B,James W. Meador,Rose Ann Ferre,Edward L. Brown,Susan L. Binford,James E. V. Harr,and Dorothy M. DeLisle,Stephen T. Worland +21 more
TL;DR: The structure-based design, chemical synthesis, and biological evaluation of various peptide-derived human rhinovirus (HRV) 3C protease (3CP) inhibitors are described and an optimized inhibitor which incorporates several improvements identified by the structure-activity studies is described.
Journal ArticleDOI
Design, synthesis and X-ray crystallographic studies of novel FKBP-12 ligands
Babine Robert E,Ted M. Bleckman,Charles R. Kissinger,Richard E. Showalter,L. A. K. Pelletier,C. T. Lewis,Kathleen D. Tucker,Ellen W. Moomaw,Hans E. Parge,J. Ernest Villafranca +9 more
TL;DR: Using the crystal structure of FKBP-12, a novel class of ligands were designed, prepared and evaluated in this article, where the crystal structures of the complex between 5 and 12 were reported.
Patent
Antipicornaviral compounds and methods for their use and preparation
Stephen E. Webber,Peter S. Dragovich,Thomas J. Prins,Reich Siegfried Heinz,Little Thomas L,Littlefield Ethel S,Marakovits Joseph T,Babine Robert E,Ted M. Bleckman +8 more
TL;DR: In this paper, the picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the 3-C proteases, and are suitable for treating patients or hosts infected with one or more of the aforementioned viruses.
Patent
Inhibitors of picornavirus 3c proteases and methods for their use and preparation
Stephen E. Webber,Peter S. Dragovich,Thomas J. Prins,Reich Siegfried Heinz,Little Thomas L,Littlefield Ethel S,Marakovits Joseph T,Babine Robert E,Bleckman Ted M +8 more
TL;DR: In this article, the picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the 3-C proteases, and are suitable for treating patients or hosts infected with one or more of the aforementioned viruses.