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Barbara Francis
Researcher at Merck & Co.
Publications - 12
Citations - 373
Barbara Francis is an academic researcher from Merck & Co.. The author has contributed to research in topics: In vivo & Receptor. The author has an hindex of 9, co-authored 12 publications receiving 371 citations.
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Journal Article
Receptor-Binding Radiotracers: A Class of Potential Radiopharmaceuticals
William C. Eckelman,R.C. Reba,Raymond E. Gibson,W. J. Rzeszotarski,Frank Vieras,J.K. Mazaitis,Barbara Francis +6 more
TL;DR: Theoretical calculations showed that derivatives binding to the estrogen receptor, the beta adrenoceptor, or the cholinergic receptor are capable of achieving satisfactory target-to-blood ratios.
Journal Article
[I-125] 17 alpha-Iodovinyl 11 beta-methoxyestradiol: in vivo and in vitro properties of a high-affinity estrogen-receptor radiopharmaceutical.
Elaine M. Jagoda,Raymond E. Gibson,Henry Goodgold,Nelson Ferreira,Barbara Francis,Richard C. Reba,W. J. Rzeszotarski,William C. Eckelman +7 more
TL;DR: By in vivo competition studies with nonradioactive estradiol, it is found that 95% of the [I-125]MIVE2 bound in the uterus is specifically bound to estrogen receptors.
Journal ArticleDOI
Synthesis and evaluation of radioiodinated derivatives of 1-azabicyclo[2.2.2]oct-3-yl .alpha.-hydroxy-.alpha.-(4-iodophenyl)-.alpha.-phenylacetate as potential radiopharmaceuticals
W. J. Rzeszotarski,W. C. Eckelman,Barbara Francis,D. A. Simms,Raymond E. Gibson,Elaine M. Jagoda,Michael P. Grissom,R.R. Eng,J. J. Conklin,R. C. Reba +9 more
TL;DR: Preliminary distribution studies indicate that 1b localizes in the organs known to have a large concentration of muscarinic receptors and that this localization is due to binding to those receptors.
Journal ArticleDOI
Synthesis and evaluation of (17.alpha.,20E)-21-[125I]iodo-19-norpregna-1,3,5(10),20-tetraene-3,17-diol and (17.alpha.,20E)-21-[125I]iodo-11.beta.-methoxy-19-norpregna-1,3,5(10),20-tetraene-3,17-diol [17.alpha.-iodovinyl)estradiol derivatives] as high specific activity potential radiopharmaceuticals
Iwao Nakatsuka,Nelson L. Ferreira,W. C. Eckelman,Barbara Francis,W. J. Rzeszotarski,Raymond E. Gibson,Elaine M. Jagoda,R. C. Reba +7 more
TL;DR: Preliminary distribution studies indicate that although both 4b and 4d localize in the tissues known to have a large concentration of estrogen receptors, 4d accumulates in higher amounts in target tissues and provides a high target to nontarget ratio.
Journal Article
Use of 3-quinuclidinyl 4-iodobenzilate as a receptor binding radiotracer.
TL;DR: 3-Quinuclidinyl 4-iodobenzilate was shown to bind to the muscarinic acetylcholine receptor (mAChR) by testing the saturability and the stereoselectivity in the corpus striatum, cerebellum, and the heart, but the ratio of radioactivity in tissues containing different concentrations of mAChR was less than the ratio in vitro saturation assay.