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Barbara J. Schiemann
Researcher at Anschutz Medical Campus
Publications - 3
Citations - 364
Barbara J. Schiemann is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 3, co-authored 3 publications receiving 347 citations.
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SPARC Inhibits Epithelial Cell Proliferation in Part through Stimulation of the Transforming Growth Factor-β–Signaling System
TL;DR: These findings identify a novel mechanism whereby SPARC inhibits epithelial cell proliferation by selectively commandeering the TGF-beta signaling system, doing so through coupling of SPARC-EC to a T GF-beta receptor- and Smad2/3-dependent pathway.
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Fibulin-5 initiates epithelial–mesenchymal transition (EMT) and enhances EMT induced by TGF-β in mammary epithelial cells via a MMP-dependent mechanism
TL;DR: Monitoring alterations in the actin cytoskeleton and various markers of EMT shows that the TGF-beta gene target, fibulin-5 (FBLN5), initiates EMT and enhances that induced by T GF-beta, and identifies a novel E MT and tumor-promoting function for FBLN 5 in developing and progressing breast cancers.
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The use of cystatin C to inhibit epithelial–mesenchymal transition and morphological transformation stimulated by transforming growth factor-β
TL;DR: Findings show that TGF-β stimulation of initiating metastatic events, including decreased cell polarization, reduced cell–cell contact, and elevated cell invasion and migration, are prevented by CystC treatment, and suggest that the future development of CyStC or its peptide mimetics hold the potential to improve the therapeutic response of human breast cancers regulated by TGF.