Baron Shopsin

TL;DR: Hospitalized bipolar and unipolar endogenously depressed patients who showed an antidepressant response to the monoamine oxidase (MAO) inhibitor, tranylcypromine sulfate, relapsed when relatively small doses of parachlorophenylalanine (PCPA) were added for brief periods, suggesting serotonergic mechanisms are likely involved in the antidepressant effects of both the tricyclic drugs and MAO inhibitors in man.

TL;DR: Urinary excretion levels of MHPG in one of the patients studied longitudinally did not correspond to the direction of clinical affective state but did reflect anticipated changes during alpha-MPT treatment, suggesting that serotonergic mechanisms are likely involved in the anti-depressant effects of imipramine in man.

TL;DR: Qualitative differences between lithium carbonate and haloperidol indicate that, while haloperodol has a more dramatically rapid impact on behavior-motor activity, lithium Carbonate acted more evenly on the entire manic picture, with total normalization realized during active treatment.

TL;DR: Peripheral blood specimens from 22 hospitalized psychiatric patients and one outpatient were examined for white blood cell count changes during treatment with lithium carbonate; a trend toward neutrophilia and lymphocytopenia emerged but cannot be said to account for the global change in total WBG.

TL;DR: The data suggest that clozapine in the present population of newly admitted, acutely psychotic schizophrenic individuals, and in the doses employed, was more effective in overall improvement response, discharge rate, and ameliorating discrete symptoms across the different objective rating scales used than was chlorpromazine (Thorazine) hydrochloride.