B
Barry K. Wershil
Researcher at Harvard University
Publications - 22
Citations - 2146
Barry K. Wershil is an academic researcher from Harvard University. The author has contributed to research in topics: Mast cell & Immunoglobulin E. The author has an hindex of 18, co-authored 22 publications receiving 2102 citations. Previous affiliations of Barry K. Wershil include University of California, San Francisco & Beth Israel Deaconess Medical Center.
Papers
More filters
Journal ArticleDOI
Cytokine production by mast cells and basophils
TL;DR: Findings suggest that an important mechanism by which mast cells influence biological responses is through the production of a broad panel of multifunctional cytokines, while the extent to which basophils can produce cytokines is uncertain.
Journal Article
The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis.
TL;DR: It is demonstrated that SCF can regulate the survival of a cellular lineage which expresses the SCFR by suppressing apoptosis, and a mechanism that can result in striking and rapid reductions in the size of tissue mast cell populations without histological evidence of the concomitant induction of a significant inflammatory response is identified.
Journal ArticleDOI
Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent. Partial inhibition of the reaction with antiserum against tumor necrosis factor-alpha.
TL;DR: It is indicated that TNF-alpha contributes to mast cell-dependent recruitment of leukocytes during IgE-dependent cutaneous late phase reactions, but it is suggested that other mastcell-associated mediators probably also contribute to this response.
Journal Article
125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells.
TL;DR: The experiments demonstrate the utility of a novel model system for the analysis of mast cell function in vivo: WBB6F1-W/Wv mice locally reconstituted with mast cells by the injection of mast cells generated in vitro.
Journal ArticleDOI
Substance P-induced augmentation of cutaneous vascular permeability and granulocyte infiltration in mice is mast cell dependent.
TL;DR: The effects of substance P on tissue swelling, vascular permeability, and granulocyte infiltration were virtually entirely mast cell dependent.