Bas Kreike

TL;DR: Genes encoding important breast cancer-related proteins are studied using a model for survival-type data that is based on natural splines and the Cox proportional hazard model, thereby removing the linearity assumption, and EGFR-expression seems to have a non-linear relation with disease outcome.

TL;DR: The objective of the UPGRADE-RT trial is to investigate whether de-escalation of elective radiation dose and the introduction of an intermediate dose-level for borderline sized lymph nodes in the treatment of head and neck cancer will result in less radiation sequelae and improved quality of life after treatment without compromising the recurrence rate in the electively treated neck.

TL;DR: The issues raised by Rakha and colleagues in their response to the recent research article are addressed and it is shown that some of these tumours have the gene expression pattern of triple-negative tumours – these are in fact the TNP tumours from this unselected series of tumours.

TL;DR: Although prophylactic antibiotics during chemoradiotherapy for patients with LAHNC did not reduce the incidence of pneumonias, it did reduce hospitalisation rates and episodes with fever significantly and consequently tended to be cost-effective.

TL;DR: Using supervised classification, a gene expression classifiers of 35 genes differed between DCIS and invasive breast cancer; a classifier of 43 genes could be identified separating between well- and poorly differentiated DCIS samples.