A method of treating cancer and compositions of use in such a method, the method including the step of administering, either sequentially or simultaneously, (i) a compound of the xanthenone acetic acid group of compounds, and (ii) at least one compound selected from compounds which modulate TNF production and compounds which act on biochemical pathways leading to TNF synthesis, the composition including a combination of (i) and (ii) above together with acceptable pharmaceutical carriers and/or vehicles.

Cancer treatment by combination therapy

The present invention relates to synergistic combinations of the compounds of formula I such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and NSAIDs, in particular diclofenac, which have anti-tumour activity. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing said combinations.

Anti-cancer combinations

The present invention relates to the use of compounds such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) for the treatment of cancer, wherein the compounds are administered gastrointestinally, preferably orally. More particularly, the invention is concerned with the use of such compounds, wherein the compound is delivered to the site of action in the patient to be treated in two or more doses.

Anti-cancer composition comprising dmxaa or related compound

Cancer therapy using interleukin-2 and flavone compounds

Substituted six-membered benzo-fused heterocycles of the formula (I) ##STR1## in which: X=0, NH, S→(O)n (n=0 or 2); R1 is phenyl, phenyl substituted by methoxy, hydroxy, chlorine, fluorine, diethylaminoethoxy, phenoxy, 2-methyl-4-thiazolyl, 2-amino-4-thiazolyl, phenyl, amino, nitro, terbutyl, carboxymethyl, acetamido, dimethyltriazenyl, benzoyl, hexyl, undecyl, trifluoromethyl, carbamoyl; or R1 is trifluoromethyl, pyridyl-2,pyridyl-4; R2 is H, methoxy, hydroxy; or R1 and R2 are --CH═CH--CH═CH--; R3 and R4 are methoxy, hydroxy, fluorine or form a fused benzene ring; CR5 R6 R7 is carboxymethyl, --CH2 --PO3 H,--CH2 --PO(oET)2, 4-methylpiperazinyl, aminomethyl,3-4-5-trimethoxyphenylaminomethyl, acetyl, bromoacetyl, hydroxyethyl, acetoxyethyl, mercaptomethyl, acetylthiomethyl, methoxy-carbopnylthiomethyl, --CH--CONH2, ##STR2## substituted thiazolyl, subsituted furanone, imidazo(1,2-a)pyridinyl, indolizinyl, or R4 and R5 form a fused benzene ring on the positions 5 and 6, 6 and 8 or 7 and 8 are disclosed. These compounds possess anticancer activity in particular antipancreatic cancer activity together with immunomodulating activity.

Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety

The invention concerns: (oxo-4-4H-(1)-benzopyran-8-yl) alkanoic acids and their derivatives, their manufacture, represented by the formula: ##STR1## where Ar is hydrogen, a phenyl radical which may or may not be substituted, thenyl, furyl, naphthyl, a lower alkyl, cycloalkyl, aralkyl radical; B is a linear or branched lower alkyl radical, either saturated or ethylinically unsaturated; R1 is hydrogen or a phenyl radical; X is hydrogen or a lower alkyl or alkoxy radical and n=1, as well as salts, esters, aminoesters and amides. Compounds and their derivatives may be used as medicines, in particular in the control of tumors.

[Oxo-4-4H-[1]-benzopyran-8-yl]alcanoic acids, salts and derivatives, their manufacture and medicines containing them

L'invention concerne des acides [oxo-4-4H-[1]-benzopyran-8-yl] alcanoiques et leurs derives, et preparation, representes par la formule The invention relates to acid [oxo-4-4H- [1] benzopyran-8-yl] alkanoic acids and derivatives thereof, and preparation, represented by the formula dans laquelle AR est l'hydrogene, un radical phenyle substitue ou non, thenyle, furyle, naphtyle, alkyle inferieur, cycloalkyle, aralkyle; wherein AR is hydrogen, a substituted phenyl radical or not, thenyl, furyl, naphthyl, lower alkyl, cycloalkyl, aralkyl; B est un radical alkyle inferieur lineaire ou ramifie, sature ou a insaturation ethylenique; B is a linear or branched lower alkyl radical, saturated or ethylenically unsaturated; R 1 est l'hydrogene ou un radical phenyle; R 1 is hydrogen or a phenyl radical; X est l'hydrogene ou un radical alkyle inferieur, alkoxy et n = 1, ainsi que les sels, esters, aminoesters et amides. X is hydrogen or a lower alkyl, alkoxy and n = 1, and salts, esters, amino esters and amides. Les composes et leurs derives sont utilisable comme medicament notamment antitumoraux. The compounds and their derivatives are used as antitumor drug in particular.

(4-oxo-4h-(1)-benzopyran-8-yl)-alkanoic acids, salts and derivatives, preparation and medicines containing them

L'invention concerne des acides [oxo-4-4H-[1]-benzopyran-8-yl] alcanoiques et leurs derives, et preparation, representes par la formule
 dans laquelle AR est l'hydrogene, un radical phenyle substitue ou non, thenyle, furyle, naphtyle, alkyle inferieur, cycloalkyle, aralkyle; B est un radical alkyle inferieur lineaire ou ramifie, sature ou a insaturation ethylenique; R 1 est l'hydrogene ou un radical phenyle; X est l'hydrogene ou un radical alkyle inferieur, alkoxy et n = 1, ainsi que les sels, esters, aminoesters et amides. Les composes et leurs derives sont utilisable comme medicament notamment antitumoraux.

Berthelon Jean-Jacques

Papers

[Oxo-4-4H-[1]-benzopyran-8-yl]alcanoic acids, salts and derivatives, their manufacture and medicines containing them

(4-oxo-4h-(1)-benzopyran-8-yl)-alkanoic acids, salts and derivatives, preparation and medicines containing them

Acides (oxo-4-4H-(1)-benzopyran-8-yl) alcanoiques, sels et dérivés, préparation et médicaments les contenant