Bozzoli C

TL;DR: C3 levels measured in sera from male subjects without previous ischemic events are independently associated with the risk of MI, and a separate analysis for the sexes showed that serum C3 was a particularly powerful predictor of MI in men.

TL;DR: To assess the possible involvement of humoral immunity in diffuse atherosclerosis, IgG, IgA, IgM, C3 and C4 were measured in the sera of 23 atherosclerotic subjects and of 20 controls to assess whether these parameters were independently associated with Atherosclerosis.

TL;DR: Univariate analysis showed a 'ring' of highly significant correlations (P less than 0.0001) involving serum lipids and complement components (TC-C4-C3-TG-TC) and the correlation between TC and C4 was present only in men in multivariate analysis and improved with increasing age.

TL;DR: This study indicates that total serum IgA is a marker of previous major ischemic events (protracted immune response to denatured proteins?), rather than a factor predisposing to atherosclerosis development.

TL;DR: C3, C4 and fibrinogen were correlated and were associated with previous myocardial infarction, although this association persisted only for C4 in multivariate analysis and none of the coagulative variables directly involved in the complement system differed significantly in the two groups.