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Bradford T. Stokes
Researcher at Ohio State University
Publications - 82
Citations - 7175
Bradford T. Stokes is an academic researcher from Ohio State University. The author has contributed to research in topics: Spinal cord & Spinal cord injury. The author has an hindex of 36, co-authored 82 publications receiving 6945 citations. Previous affiliations of Bradford T. Stokes include University of Florida & Dorothea Dix Hospital.
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Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats.
TL;DR: Trauma‐induced central nervous system (CNS) inflammation, regardless of strain, occurs rapidly at the site of injury and involves the activation of resident and recruited immune cells.
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Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury.
TL;DR: Data implicate hematogenous (blood-derived) macrophages as effectors of acute secondary injury and suggest cell-specific immunomodulation may prove useful as an adjunct therapy after spinal cord injury.
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Neurotrophin-3 and Brain-Derived Neurotrophic Factor Induce Oligodendrocyte Proliferation and Myelination of Regenerating Axons in the Contused Adult Rat Spinal Cord
TL;DR: The association of these new oligodendrocytes with ingrowing myelinated axons suggests that NT-3- and BDNF-induced myelinogenesis resulted, at least in part, from expansion of oligodendedrocyte lineage cells, most likely the endogenous oligod endocrine progenitors.
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Proliferation of NG2-Positive Cells and Altered Oligodendrocyte Numbers in the Contused Rat Spinal Cord
TL;DR: Overall, proliferation was markedly elevated during the first 2 weeks after injury and declined thereafter; a large portion of these dividing cells likely consisted of microglia–macrophages, while protracted proliferation in surviving NG2+ cells was noted, with values sevenfold greater than in uninjured controls.
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Cytokine mRNA Profiles in Contused Spinal Cord and Axotomized Facial Nucleus Suggest a Beneficial Role for Inflammation and Gliosis
Wolfgang J. Streit,Susan L. Semple-Rowland,Sean D. Hurley,Rehae Miller,Phillip G. Popovich,Bradford T. Stokes +5 more
TL;DR: In this article, a comparative analysis using semiquantitative reverse transcription polymerase chain reaction (RT-PCR) showed an early and robust upregulation of IL-1β, TNF-α, IL-6, and macrophage colony stimulating factor (M-CSF) mRNAs in spinal cord after contusion injury.