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Bradley J. Martin
Researcher at Osiris Therapeutics, Inc.
Publications - 14
Citations - 5502
Bradley J. Martin is an academic researcher from Osiris Therapeutics, Inc.. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 7, co-authored 14 publications receiving 5366 citations.
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Journal ArticleDOI
Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics
TL;DR: HMSCs isolated from adult bone marrow provide an excellent model for development of stem cell therapeutics, and their potential use in the cardiovascular system is currently under investigation in the laboratory and clinical settings.
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Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction
Luciano C. Amado,Anastasios Saliaris,Karl H. Schuleri,Marcus E. St. John,Jin Sheng Xie,Stephen M. Cattaneo,Daniel J. Durand,Torin P. Fitton,Jin Qiang Kuang,Garrick C. Stewart,Stephanie Lehrke,William W. Baumgartner,Bradley J. Martin,Alan W. Heldman,Joshua M. Hare +14 more
TL;DR: The results of a randomized study of bone-marrow-derived mesenchymal stem cells, administered to pigs, which offer several new insights regarding cellular cardiomyoplasty demonstrate that the direct injection of cellular grafts into damaged myocardium is safe and effective in the perii-nfarct period.
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Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects.
Jay G. Shake,Peter J. Gruber,William A. Baumgartner,Guylaine Senechal,Jennifer Meyers,J.Mark Redmond,Mark F. Pittenger,Bradley J. Martin +7 more
TL;DR: Mesenchymal stem cells are capable of engraftment in host myocardium, demonstrate expression of muscle specific proteins, and may attenuate contractile dysfunction and pathologic thinning in this model of left ventricular wall infarction.
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Mesenchymal Stem Cells Differentiate into an Endothelial Phenotype, Enhance Vascular Density, and Improve Heart Function in a Canine Chronic Ischemia Model
Guilherme V. Silva,Silvio H. Litovsky,Joao A.R. Assad,Andre L.S. Sousa,Bradley J. Martin,Deborah Vela,Stephanie Coulter,Jing Lin,Judy Ober,William K. Vaughn,Rodrigo Branco,Edie M. Oliveira,Rumin He,Yong-Jian Geng,James T. Willerson,Emerson C. Perin +15 more
TL;DR: In a canine chronic ischemia model, MSCs differentiated into smooth muscle cells and endothelial cells, resulting in increased vascularity and improved cardiac function in the treated group.
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In Vivo Magnetic Resonance Imaging of Mesenchymal Stem Cells in Myocardial Infarction
Dara L. Kraitchman,Alan W. Heldman,Ergin Atalar,Ergin Atalar,Luciano C. Amado,Bradley J. Martin,Mark F. Pittenger,Joshua M. Hare,Jeff W.M. Bulte +8 more
TL;DR: MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of M SCs in MI.