B
Brady K. Atwood
Researcher at Indiana University
Publications - 59
Citations - 2594
Brady K. Atwood is an academic researcher from Indiana University. The author has contributed to research in topics: Medicine & Striatum. The author has an hindex of 17, co-authored 42 publications receiving 1973 citations. Previous affiliations of Brady K. Atwood include University of Washington & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
CB2: a cannabinoid receptor with an identity crisis
TL;DR: This review will discuss the reported tissue distribution of CB2 with a focus on CB2 in neurons, particularly those in the central nervous system as well as the implications of that presence.
Journal ArticleDOI
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
TL;DR: This study provides researchers an easily accessible mRNA profile of the endogenous signaling repertoire that these four cell lines possess, which will assist in choosing the most appropriate cell line for studying GPCRs and related signaling proteins.
Journal ArticleDOI
JWH018, a common constituent of ‘Spice’ herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist
TL;DR: In this paper, the effects of JWH018 on neurotransmission in cultured autaptic hippocampal neurons were investigated, and it was shown that the indole derivative is a ligand for the CB1 (CB1) cannabinoid receptor and inhibits cAMP production in CB1 receptor-expressing CHO cells.
Journal ArticleDOI
Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation
Christina M. Gremel,Jessica H. Chancey,Brady K. Atwood,Guoxiang Luo,Rachael L. Neve,Charu Ramakrishnan,Karl Deisseroth,David M. Lovinger,Rui M. Costa +8 more
TL;DR: An endogenous molecular mechanism in a specific cortical-striatal pathway that mediates the transition between goal-directed and habitual action strategies is identified and suggests that the emergence of habits depends on endocannabinoid-mediated attenuation of a competing circuit controlling goal- directed behaviors.
Journal ArticleDOI
Functional selectivity in CB2 cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB2 ligands
TL;DR: The most striking finding was that (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo]-1-naphthalenyl-methanone (WIN55,212-2) (and other aminoalkylindoles) failed to promote CB2 receptor internalization, whereas 5-(1,1-dimethylheptyl)-2-(5-hydroxy-2