B
Bregje van Oorschot
Researcher at University of Amsterdam
Publications - 8
Citations - 164
Bregje van Oorschot is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Prostate cancer & Toxicity. The author has an hindex of 7, co-authored 8 publications receiving 136 citations.
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Journal ArticleDOI
Reduced Activity of Double-Strand Break Repair Genes in Prostate Cancer Patients With Late Normal Tissue Radiation Toxicity
Bregje van Oorschot,Suzanne Hovingh,Perry D. Moerland,Jan Paul Medema,Lukas J.A. Stalpers,Harry Vrieling,Nicolaas A. P. Franken +6 more
TL;DR: Gene expression profiling and DNA DSB repair kinetics data imply that less-efficient repair of radiation-induced DSBs may contribute to the development of late normal tissue damage.
Journal ArticleDOI
Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment.
Bregje van Oorschot,Giovanna Granata,Simone Di Franco,Rosemarie ten Cate,Hans M. Rodermond,Matilde Todaro,Jan Paul Medema,Nicolaas A. P. Franken +7 more
TL;DR: In this paper, the effect of DNA double-strand-break repair with hyperthermia (HT) and DNA-PKcs inhibitor NU7441 (DN) was investigated in cervical and breast cancer cells.
Journal ArticleDOI
Predicting Radiosensitivity with Gamma-H2AX Foci Assay after Single High-Dose-Rate and Pulsed Dose-Rate Ionizing Irradiation.
Bregje van Oorschot,Suzanne Hovingh,Annelot Dekker,Lukas J.A. Stalpers,Nicolaas A. P. Franken +4 more
TL;DR: In this article, the authors investigated the induction and decay of γ-H2AX foci of different tumor cell lines and fibroblasts with known mutations in DNA damage repair genes, including ATM, LigIV, DNA-PKcs, Rad51 and Rad54.
Journal ArticleDOI
Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells.
Bregje van Oorschot,Suzanne Hovingh,Hans M. Rodermond,Ahmed Güçlü,Nienke Losekoot,Albert A. Geldof,G. W. Barendsen,Lukas J.A. Stalpers,Nicolaas A. P. Franken +8 more
TL;DR: A clear correlation was demonstrated between the degree of decay of γ-H2AX foci and PLDR and the LNCaP cells which demonstrated a clear PLDR also showed the largest decay in the number of €foci, while the PC cells which did not show PLDR had the lowest decay.
Journal ArticleDOI
Prostate cancer patients with late radiation toxicity exhibit reduced expression of genes involved in DNA double strand break repair and homologous recombination.
Bregje van Oorschot,L. Uitterhoeve,Ilja Oomen,Rosemarie ten Cate,Jan Paul Medema,Harry Vrieling,Lukas J.A. Stalpers,Perry D. Moerland,Nicolaas A. P. Franken +8 more
TL;DR: Evidence of prognostic utility in prostate cancer for γ-H2AX foci decay ratios and gene expression profiles derived from ex vivo-irradiated patient lymphocytes is reported, suggesting a prognostic biomarker for cancer patients with a genetically enhanced risk for late radiation toxicity to normal tissues after radiotherapy.