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Showing papers by "Brendan Gilmore published in 2004"

Journal Article•DOI•
Phototoxicity of 5-aminolevulinic acid in the HeLa cell line as an indicative measure of photodynamic effect after topical administration to gynecological lesions of intraepithelial form.

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Paul A. McCarron1, Ryan F. Donnelly1, Brendan Gilmore1, A. David Woolfson1, Raymond McClelland2, Agnieszka Zawislak2, J.H. Price2 •
Queen's University Belfast1, Belfast City Hospital2
01 Oct 2004-Pharmaceutical Research
TL;DR: The depth-resolved pattern of aminolevulinic acid concentration in excised vaginal tissue was determined and it was found that vaginal intraepithelial neoplasias can extend to 2.0 mm from the lesion surface, the ALA permeability derived from a bioadhesive patch is sufficient to induce photosensitization suitable for light induced destruction at deep sites of this type of lesion.
Abstract: Purpose. The depth-resolved pattern of aminolevulinic acid (ALA) concentration in excised vaginal tissue was determined after in vitro application of an ALA-loaded bioadhesive patch. From this data, the tissue concentration of ALA achievable at a specified depth from the surface could be related to the concentration needed to elicit a photodynamic effect in a model gynecological tumor cell line (HeLa).

19 citations