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Brian F. Hinnebusch
Researcher at Beth Israel Deaconess Medical Center
Publications - 7
Citations - 771
Brian F. Hinnebusch is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Enterocyte differentiation & Regulation of gene expression. The author has an hindex of 7, co-authored 7 publications receiving 710 citations. Previous affiliations of Brian F. Hinnebusch include Harvard University.
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Journal ArticleDOI
The Effects of Short-Chain Fatty Acids on Human Colon Cancer Cell Phenotype Are Associated with Histone Hyperacetylation
TL;DR: The data suggest that the antiproliferative, apoptotic and differentiating properties of the various SCFA are linked to the degree of induced histone hyperacetylation.
Journal ArticleDOI
Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor.
Brian F. Hinnebusch,Aleem Siddique,J. Welles Henderson,Madhu S. Malo,Wenying Zhang,Christopher P. Athaide,Mario A. Abedrapo,Xin-Ming Chen,Vincent W. Yang,Richard A. Hodin +9 more
TL;DR: The enterocyte differentiation marker IAP is identified as a KLF4 target gene and is likely mediated through a critical region located within the proximal IAP promoter region that includes the IF-III cis-element.
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Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis.
TL;DR: The role of histone hyperacetylation in regard to growth, differentiation, and apoptosis in colon cancer cells was assessed in an in vitro model system as mentioned in this paper, where HT-29 cells were grown in ±10% fetal bovine serum with either 5 mM sodium butyrate or 0.3 μM trichostatin A [single dose (T) or 3 doses 8 h apart (TR)] for 24 hours.
Journal ArticleDOI
Enterocyte response to ischemia is dependent on differentiation state.
Brian F. Hinnebusch,Qing Ma,J. Welles Henderson,Aleem Siddique,Sonia Y. Archer,Richard A. Hodin +5 more
TL;DR: This article found that differentiated cells are more sensitive to ischemia-induced injury than their undifferentiated counterparts, and that the differentiated cells at the tips of microvilli are more susceptible to ischemic injury than those residing in the crypts.
Journal ArticleDOI
Transcriptional activation of the enterocyte differentiation marker intestinal alkaline phosphatase is associated with changes in the acetylation state of histone H3 at a specific site within its promoter region in vitro
Brian F. Hinnebusch,J. Welles Henderson,Aleem Siddique,Madhu S. Malo,Wenying Zhang,Mario A. Abedrapo,Richard A. Hodin +6 more
TL;DR: It is concluded that butyrate-induced differentiation is associated with specific and localized changes in the histone acetylation state within the IAP promoter, which may underlie its transcriptional activation in the context of the enterocyte differentiation program.