B
Brian G. Poll
Researcher at Johns Hopkins University
Publications - 11
Citations - 163
Brian G. Poll is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Keratin 17 & Medicine. The author has an hindex of 5, co-authored 8 publications receiving 113 citations. Previous affiliations of Brian G. Poll include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes
Ryan P. Hobbs,Daryle Depianto,Justin T. Jacob,Minerva C. Han,Byung Min Chung,Adriana S. Batazzi,Brian G. Poll,Yajuan Guo,Jingnan Han,SuFey Ong,Wenxin Zheng,Janis M. Taube,Daniela Cihakova,Fengyi Wan,Pierre A. Coulombe +14 more
TL;DR: It is reported that autoimmune regulator (Aire), a transcriptional regulator, is inducibly expressed in human and mouse tumor keratinocytes in a K17-dependent manner and is required for timely onset of Gli2-induced skin tumorigenesis in mice.
Journal ArticleDOI
Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.
TL;DR: A role for defective terminal differentiation and loss of Krt9/K9 expression as additional drivers of PC-associated PPK is highlighted and restoration of KRT9 expression is highlighted as a worthy target for therapy.
Journal ArticleDOI
Short‐chain fatty acid delivery: assessing exogenous administration of the microbiome metabolite acetate in mice
TL;DR: These studies report, for the first time, the timecourse of changes in plasma acetate following acetate administration by three common methods, and thus inform the best practices for exogenous acetate delivery.
Posted ContentDOI
Keratin 17 regulates nuclear morphology and chromatin organization
Justin T. Jacob,Raji R. Nair,Raji R. Nair,Brian G. Poll,Christopher M. Pineda,Ryan P. Hobbs,Michael J. Matunis,Pierre A. Coulombe +7 more
TL;DR: K17 is shown to regulate nuclear morphology, chromatin organization, LAP2 localization, and cell proliferation in epithelial cells, and is associated with decreased cell proliferation and suppression of GLI1 target genes.
Journal ArticleDOI
Keratin 17 regulates nuclear morphology and chromatin organization.
Justin T. Jacob,Raji R. Nair,Raji R. Nair,Brian G. Poll,Christopher M. Pineda,Ryan P. Hobbs,Michael J. Matunis,Pierre A. Coulombe +7 more
TL;DR: K17 is shown to regulate nuclear morphology, chromatin organization, LAP2 localization and cell proliferation in epithelial cells, and is associated with decreased cell proliferation and suppression of GLI1 target genes.