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Brian T. Hawkins
Researcher at Duke University
Publications - 54
Citations - 4816
Brian T. Hawkins is an academic researcher from Duke University. The author has contributed to research in topics: Blood–brain barrier & Tight junction. The author has an hindex of 22, co-authored 49 publications receiving 4242 citations. Previous affiliations of Brian T. Hawkins include University of Arizona & National Institutes of Health.
Papers
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Journal ArticleDOI
The Blood-Brain Barrier/Neurovascular Unit in Health and Disease
Brian T. Hawkins,Thomas P. Davis +1 more
TL;DR: Understanding how BBB TJ might be affected by various factors holds significant promise for the prevention and treatment of neurological diseases.
Journal ArticleDOI
Increased blood–brain barrier permeability and altered tight junctions in experimental diabetes in the rat: Contribution of hyperglycaemia and matrix metalloproteinases
TL;DR: These data indicate that diabetes increases BBB permeability via a loss of tight junction proteins, and that increased BB B permeability in diabetes does not result from hyperglycaemia alone.
Journal ArticleDOI
Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution
Brian T. Hawkins,Thomas J. Abbruscato,Richard D. Egleton,Rachel C. Brown,Jason D. Huber,Christopher R. Campos,Thomas P. Davis +6 more
TL;DR: It was found that continuous administration of nicotine for 1 and 7 days led to increased permeability of the blood-brain barrier to [14C]-sucrose without significant changes in its initial volume of distribution.
Journal ArticleDOI
Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells.
TL;DR: Evidence is provided that nicotine and cotinine alter BBB permeability and tight junctional protein expression of ZO-1, thereby altering the BBB response to stroke conditions.
Journal ArticleDOI
Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations
TL;DR: During chronic inflammatory pain, alterations in BBB function are associated with changes in specific transmembrane TJ proteins, demonstrating that the blood-brain barrier can be modulated by disease pathologies including inflammatory pain.