B
Bronwyn G. Siim
Researcher at Baylor University
Publications - 4
Citations - 104
Bronwyn G. Siim is an academic researcher from Baylor University. The author has contributed to research in topics: Cathepsin & Combretastatin. The author has an hindex of 4, co-authored 4 publications receiving 96 citations.
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Journal ArticleDOI
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
G.D. Kishore Kumar,Gustavo E. Chavarria,Amanda K. Charlton-Sevcik,Wara M. Arispe,Matthew T. MacDonough,Tracy E. Strecker,Shen-En Chen,Bronwyn G. Siim,David J. Chaplin,Mary Lynn Trawick,Kevin G. Pinney +10 more
TL;DR: The most active analog in the series, 3-bromophenyl-2′-fluorophenyl thiosemicarbazone 1, also efficiently inhibits cell invasion of the DU-145 human prostate cancer cell line.
Journal ArticleDOI
Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.
G.D. Kishore Kumar,Gustavo E. Chavarria,Amanda K. Charlton-Sevcik,Grace Kim Yoo,Jiangli Song,Tracy E. Strecker,Bronwyn G. Siim,David J. Chaplin,Mary Lynn Trawick,Kevin G. Pinney +9 more
TL;DR: A series of thiosemicarbazone analogs based on the benzophenone, thiophene, pyridine, and fluorene molecular frameworks has been prepared by chemical synthesis and evaluated as small-molecule inhibitors of the cysteine proteases cathepsin L and cat hepsin B.
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Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1.
Rajendra P. Tanpure,Benson L. Nguyen,Tracy E. Strecker,Savannah Aguirre,Suman Sharma,David J. Chaplin,Bronwyn G. Siim,Ernest Hamel,John W. Lippert,George R. Pettit,Mary Lynn Trawick,Kevin G. Pinney +11 more
TL;DR: The first synthetic routes suitable for the regiospecific preparation of the CA1-monophosphates CA1MPA and CA1MPB are described, and each of the four monophosphate analogues demonstrated in vitro cytotoxicity against selected human cancer cell lines comparable to their corresponding diphosphate congeners.
Journal ArticleDOI
Regio- and Stereospecific Synthesis of Mono-β-d-Glucuronic Acid Derivatives of Combretastatin A-1
Rajendra P. Tanpure,Tracy E. Strecker,David J. Chaplin,Bronwyn G. Siim,Mary Lynn Trawick,Kevin G. Pinney +5 more
TL;DR: Judicious choice of protecting groups for the catechol ring was required for the regiospecific introduction of the glucuronic acid moiety, and the tosyl group proved advantageous in this regard.