B
Bruno Silvestrini
Researcher at Sapienza University of Rome
Publications - 164
Citations - 4419
Bruno Silvestrini is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Sertoli cell & Adjudin. The author has an hindex of 35, co-authored 163 publications receiving 4023 citations.
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Journal ArticleDOI
Antioxidant superoxide dismutase - a review: its function, regulation in the testis, and role in male fertility.
TL;DR: In a more detailed survey of several rat tissues and cells by reverse transcriptase-polymerase chain reaction, it was shown that germ cells expressed approximately one-third that of Sertoli cells, suggesting both cell types are equipped with the machinery needed to defend themselves from radical-induced damage as discussed by the authors.
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Lonidamine, a Selective Inhibitor of Aerobic Glycolysis of Murine Tumor Cells
TL;DR: Lonidamine increased the aerobic glycolysis of normal cells but inhibited that of tumor cells, suggesting selective action might be ascribed to the inhibition of mitochondrially bound hexokinase, which is usually absent in normal differentiated cells.
Journal Article
Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells.
Aristide Floridi,Marco G. Paggi,S. D'Atri,De Martino C,M.L. Marcante,Bruno Silvestrini,Antonio Caputo +6 more
TL;DR: It is concluded that inhibition of the glycolysis of Ehrlich ascites tumor cells by Lonidamine results from an effect of the drug on the mitochondrially bound hexokinase.
Journal ArticleDOI
Two New Male Contraceptives Exert Their Effects by Depleting Germ Cells Prematurely from the Testis
C. Yan Cheng,Bruno Silvestrini,J Grima,Meng-yun Mo,Li-ji Zhu,Elof D.B. Johansson,Luciano Saso,Leone Mg,Maura Palmery,Dolores D. Mruk +9 more
TL;DR: An alternative approach in which attachments of developing germ cells onto the seminiferous epithelium are disrupted, thereby inducing their premature release into the tubular lumen leading to infertility is described.
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Anchoring Junctions As Drug Targets: Role in Contraceptive Development
TL;DR: A novel approach with the aim of developing a nonhormonal male contraceptive for future human use is discussed, one that involves perturbing adhesion between Sertoli and germ cells in the testis.