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Buck S. Samuel
Researcher at Baylor College of Medicine
Publications - 26
Citations - 8682
Buck S. Samuel is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Microbiome & Caenorhabditis elegans. The author has an hindex of 12, co-authored 22 publications receiving 7449 citations. Previous affiliations of Buck S. Samuel include Washington University in St. Louis & Harvard University.
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Journal ArticleDOI
Metagenomic Analysis of the Human Distal Gut Microbiome
Steven R. Gill,Mihai Pop,Robert T. DeBoy,Paul B. Eckburg,Paul B. Eckburg,Peter J. Turnbaugh,Buck S. Samuel,Jeffrey I. Gordon,David A. Relman,David A. Relman,Claire M. Fraser-Liggett,Karen E. Nelson +11 more
TL;DR: Using metabolic function analyses of identified genes, the human genome is compared with the average content of previously sequenced microbial genomes and humans are superorganisms whose metabolism represents an amalgamation of microbial and human attributes.
Journal ArticleDOI
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
Buck S. Samuel,Abdullah Shaito,Toshiyuki Motoike,Federico E. Rey,Fredrik Bäckhed,Fredrik Bäckhed,Jill K. Manchester,Robert E. Hammer,S. Clay Williams,Jan R. Crowley,Masashi Yanagisawa,Jeffrey I. Gordon +11 more
TL;DR: Functional genomic, biochemical, and physiologic studies reveal that Gpr41 is a regulator of host energy balance through effects that are dependent upon the gut microbiota.
Journal ArticleDOI
Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota.
TL;DR: Methods for producing and rearing germ-free zebrafish through late juvenile stages are developed and established as a useful model for dissecting the molecular foundations of host-microbial interactions in the vertebrate digestive tract.
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A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism
Buck S. Samuel,Jeffrey I. Gordon +1 more
TL;DR: A link between this archaeon, prioritized bacterial utilization of polysaccharides commonly encountered in the authors' modern diets, and host energy balance is demonstrated and demonstrate a link between B. thetaiotaomicron and the contributions of Archaea to digestive health.
Journal ArticleDOI
Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut
Buck S. Samuel,Elizabeth E. Hansen,Jill K. Manchester,Pedro M. Coutinho,Bernard Henrissat,Robert S. Fulton,P. Latreille,Kung Kim,Rick K. Wilson,Jeffrey I. Gordon +9 more
TL;DR: Results indicate that M. smithii is well equipped to persist in the distal intestine through production of surface glycans resembling those found in the gut mucosa, and regulated expression of adhesin-like proteins, and consumption of a variety of fermentation products produced by saccharolytic bacteria, and effective competition for nitrogenous nutrient pools.