B
Burton B. Yang
Researcher at University of Toronto
Publications - 178
Citations - 15589
Burton B. Yang is an academic researcher from University of Toronto. The author has contributed to research in topics: microRNA & Versican. The author has an hindex of 63, co-authored 163 publications receiving 12908 citations. Previous affiliations of Burton B. Yang include Sunnybrook Health Sciences Centre & Chinese Academy of Sciences.
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Journal ArticleDOI
Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2
William W. Du,Weining Yang,Elizabeth Liu,Elizabeth Liu,Zhenguo Yang,Zhenguo Yang,Preet Dhaliwal,Preet Dhaliwal,Burton B. Yang,Burton B. Yang +9 more
TL;DR: This work demonstrates that the circular RNA circ-Foxo3 was highly expressed in non-cancer cells and were associated with cell cycle progression, and formed a ternary complex that arrested the function of CDK2 and blockedcell cycle progression.
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MiRNA-Directed Regulation of VEGF and Other Angiogenic Factors under Hypoxia
Zhong L. Hua,Qing Lv,Wenbin Ye,Chung-Kwun Amy Wong,Guoping Cai,Dayong Gu,Yanhong Ji,Chen Zhao,Jifeng Wang,Burton B. Yang,Yaou Zhang +10 more
TL;DR: This work used CNE cells from a human nasopharyngeal carcinoma cell line as a cellular system to investigate miRNA-directed regulation of VEGF and other angiogenic factors under hypoxia, and to explore the principles of gene regulation by miRNAs.
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Structure and function of aggrecan
TL;DR: ABSTRACTAggrecan is the major proteoglycan in the articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties and is crucial in chondroskeletal morphogenesis during development.
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Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses
William W. Du,William W. Du,Weining Yang,Yu Chen,Zhong-Kai Wu,Francis Stuart Foster,Zhenguo Yang,Zhenguo Yang,Xiangmin Li,Xiangmin Li,Burton B. Yang,Burton B. Yang +11 more
TL;DR: It is concluded that ID-1, E2F1, FAK, and HIF1&agr; interact with circ-Foxo3 and are retained in the cytoplasm and could no longer exert their anti-senescent and anti-stress roles, resulting in increased cellular senescence.
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MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression
TL;DR: It is suggested that miR-378 transfection enhanced cell survival, tumor growth, and angiogenesis through repression of the expression of two tumor suppressors, Sufu and Fus-1.