C
C M Hill
Researcher at New York University
Publications - 4
Citations - 4155
C M Hill is an academic researcher from New York University. The author has contributed to research in topics: Chemokine receptor & CCR1. The author has an hindex of 4, co-authored 4 publications receiving 4108 citations.
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Journal ArticleDOI
Identification of a major co-receptor for primary isolates of HIV-1
Hongkui Deng,Rong Liu,Wilfried Ellmeier,S Choe,Derya Unutmaz,M Burkhart,P Di Marzio,Shoshana Marmon,R E Sutton,C M Hill,C B Davis,S C Peiper,T J Schall,Dan R. Littman,Nathaniel R. Landau +14 more
TL;DR: The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, Mip-1α and MIP-1β.
Journal ArticleDOI
Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor.
C M Hill,Hongkui Deng,Derya Unutmaz,Vineet N. KewalRamani,Lisa Bastiani,Miroslaw K. Gorny,Susan Zolla-Pazner,Dan R. Littman +7 more
TL;DR: It is shown that the envelope glycoproteins of several strains of HIV-2 and simian immunodeficiency virus (SIV) employ the same chemokine receptors for infection.
Journal ArticleDOI
The Amino Terminus of Human CCR5 Is Required for Its Function as a Receptor for Diverse Human and Simian Immunodeficiency Virus Envelope Glycoproteins
C M Hill,Douglas S. Kwon,M Jones,C B Davis,Shoshana Marmon,Bruce L. Daugherty,Julie A. DeMartino,Martin S. Springer,Derya Unutmaz,Dan R. Littman +9 more
TL;DR: Binding of several anti-CCR5 monoclonal antibodies to cell lines and primary cells that express this chemokine receptor found that whereas all antibodies bound to CCR5-transfected 293T cells, several did not bind to PBMC, suggesting that CCR 5 undergoes cell type specific structural modifications which may affect interaction with different HIV and SIV envelope glycoproteins.