C
C. Milstein
Researcher at Laboratory of Molecular Biology
Publications - 27
Citations - 21509
C. Milstein is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Monoclonal antibody & Antibody. The author has an hindex of 20, co-authored 26 publications receiving 21012 citations.
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Journal ArticleDOI
Continuous cultures of fused cells secreting antibody of predefined specificity
G Köhler,C. Milstein +1 more
TL;DR: The derivation of a number of tissue culture cell lines which secrete anti-sheep red blood cell (SRBC) antibodies is described here, made by fusion of a mouse myeloma and mouse spleen cells from an immunised donor.
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A possible precursor of immunoglobulin light chains
TL;DR: A clear discrepancy is reported between the product of certain cell-free reactions and authentic light chain and it is proposed that light chains are initially synthesized as a precursor of slightly higher molecular weight and subsequently converted into the authentic product.
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Rat × rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG
G. Galfre,C. Milstein,B Wright +2 more
TL;DR: The preparation and use of a new clone of a rat myeloma is described, suitable for the derivation of rat × rat hybrid myelomas producing specific rat antibodies.
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A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6
Franco Calabi,C. Milstein +1 more
TL;DR: The isolation of complementary DNA (cDNA) clones encoding a CD1 antigen reveal a novel family of genes which are MHC-related but are neither equivalent to mouse TL antigens nor linked to the MHC.
Journal ArticleDOI
Fusion of Two Immunoglobulin-producing Myeloma Cells
TL;DR: It is demonstrated that fusion between two immunoglobulin-secreting cell lines produces hybrid cells which secrete immunoglOBulin of both parental types.