C
C. Russell Middaugh
Researcher at University of Kansas
Publications - 297
Citations - 12886
C. Russell Middaugh is an academic researcher from University of Kansas. The author has contributed to research in topics: Circular dichroism & Protein structure. The author has an hindex of 54, co-authored 293 publications receiving 11726 citations.
Papers
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Journal ArticleDOI
Visible Light Degradation of a Monoclonal Antibody in a High-Concentration Formulation: Characterization of a Tryptophan-Derived Chromophoric Photo-product by Comparison to Photo-degradation of N-Acetyl-l-tryptophan Amide.
Indira Prajapati,Indira Prajapati,Nicholas R. Larson,Sureshkumar Choudhary,Cavan Kalonia,Suzanne Hudak,Reza Esfandiary,C. Russell Middaugh,Christian Schöneich +8 more
TL;DR: In this paper, the color change of a highly concentrated monoclonal antibody (mAbZ) in NaAc and histidine/lysine (His/Lys) buffer after exposure to visible light was investigated.
Book ChapterDOI
Molten Globule-Lipid Bilayer Interactions and Their Implications for Protein Transport and Aggregation
Book ChapterDOI
Subunit-based vaccines: challenges in developing protein-based vaccines
Salvador F. Ausar,Nicholas R. Larson,Yangjie Wei,Yangjie Wei,Akshay Jain,C. Russell Middaugh +5 more
TL;DR: In this paper, the authors consider the challenges associated with the development and use of recombinant protein-based vaccines and then provide five examples of such vaccines undergoing clinical evaluation, including vaccines for hepatitis B and human papilloma virus.
Journal ArticleDOI
Intra-micellar and extra-micellar oxidation in phosphate and histidine buffers containing polysorbate 80.
TL;DR: In this paper , the extent of extra-and intra-micellar oxidation of polysorbate in pharmaceutically relevant buffers is quantitatively quantitatively addressed.